Evidence map›Paper›PMID 36414997›Full record

ArticleActa neuropathologica communications2022

The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias.

Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. TDP-43-mediated amyotrophic lateral sclerosis: new/hidden insights fromFrontiers in cell and developmental biology · 2025
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yongping ChenDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Gopinath KrishnanDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Sepideh ParsiDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Marine PonsDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Veroniki NikolakiDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Lu CaoDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Zuoshang XuDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Fen-Biao GaoDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. fen-biao.gao@umassmed.edu.ORCID 0000-0001-8873-5404
University of Massachusetts Chan Medical School · USHarvard University · US

Funding

Investigating Common Molecular Pathogenic Pathways in Frontotemporal Dementia Patients iPSC-Derived NeuronsR01NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2008 to 2026
$4.5M
Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
Protein Arginine Deiminase 2 (PAD2) and Protein Citrullination in ALSR01NS118145 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XU, ZUOSHANG · 2021 to 2025
$2.4M
An in vivo approach to understanding mutant PFN1 toxicity on motor neuronsR01NS101895 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XU, ZUOSHANG · 2017 to 2021
$1.8M
NINDS NIH HHS R01 NS057553NINDS NIH HHS R01 NS101895NINDS NIH HHS R01 NS101986NINDS NIH HHS R01 NS118145NINDS NIH HHS R37 NS057553
6 · The paper itself

Abstract

Chromosome 3-linked frontotemporal dementia (FTD3) is caused by a gain-of-function mutation in CHMP2B, resulting in the production of a truncated toxic protein, CHMP2B

Indexed as

Drosophila ProteinsEndosomal Sorting Complexes Required for TransportFrontotemporal DementiaPick Disease of the BrainSpastic Paraplegia, HereditarySpastinAnimalsDrosophilaHumansMiceNerve Tissue ProteinsVesicular Transport ProteinsCHMP2B protein, DrosophilaCHMP2B protein, humanCHMP2B protein, mouseDrosophila ProteinsEndosomal Sorting Complexes Required for TransportNerve Tissue ProteinsSpastinSPAST protein, humanVesicular Transport ProteinsCHMP2BESCRTFrontotemporal dementiaHereditary spastic paraplegiasSpastin

Identifiers

PMID36414997
PMCPMC9682730
OpenAlexW4309673740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.