ArticleSurgical endoscopy2023
Comparative study of open, laparoscopic and endoscopic treatments of intermediate grade vesicoureteral reflux in children.
Article in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Comparative efficacy and safety of CohenPeerJ · 2026Pooled it
- Cohen versus Lich-Gregoir ureteral reimplantation for pediatric primary vesicoureteral reflux: a systematic review and meta-analysis of comparative studies.Translational pediatrics · 2026Article
- Article
- Comparison of transvesicoscopic Cohen and transvesicoscopic Politano-Leadbetter ureteral reimplantation in the treatment of ureterovesical junction obstruction (UVJO) in children: a single-center long-term follow-up study.Pediatric surgery international · 2025Article
- What paediatricians need to know about modern urologic management of vesicoureteral reflux.Frontiers in pediatrics · 2025Review
- Bilateral ureteral obstruction after open ureteral reimplantation in a 3-year-old patient with Williams Beuren syndrome.Radiology case reports · 2024Article
- Endoscopic injection vs anti-reflux surgery for moderate- and high-grade vesicoureteral reflux in children: a cost-effectiveness international study.Journal of robotic surgery · 2024Article
- Recurrence of vesico-ureteral reflux in children: is still the endoscopic injection the best option?Translational andrology and urology · 2024Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-grade vesicoureteral-reflux (VUR) are rather treated by endoscopic injection, whereas open or laparoscopic procedures are mainly performed for high-grade VURs. Management of intermediate grades is controversial and no study focused on grade III to date. This study aims to compare the results of open, laparoscopic, and endoscopic approaches in children with grade III VUR.
methodsA multicenter comparative retrospective study included children with grade III VUR operated for febrile urinary tract infections (UTIs) from 2007 to 2016. Children without UTI, with reflux of other grades, neurological bladder, duplex system, posterior urethral valves, and bladder exstrophy were excluded. Success was defined as no recurrence of febrile UTI and was presented as event-free survival curves.
resultsOut of 806 children operated of VUR, 171 met the inclusion criteria (114 females). Seventy-seven children (45%) underwent an open Cohen procedure, 35 (21%) a laparoscopic Lich-Gregoir and 59 (34%) a submucosal endoscopic injection according to the centers' preference. The mean follow-up was 64 months (24-132). Groups were not different for age, sex, and circumcision status. Compared to Cohen procedure, recurrences of febrile UTI were more frequent after laparoscopic treatment (p = 0,02, 8/35) and endoscopic treatment (p = 0.001, 16/59). Redosurgery was also more frequent after laparoscopy (n = 2) and endoscopic injection (n = 14) than after open surgery (n = 0, p < 0.001).
conclusionRecurrent febrile UTIs and redosurgery are more frequent after endoscopic and laparoscopic procedures in grade III VUR than open reimplantation. Whether the lower morbidity of laparoscopic or endoscopic approaches balances the risk of recurrent febrile UTI remains to be determined for intermediate grade reflux.
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