SynthesisProstate cancer and prostatic diseases2023
Global burden and temporal trends of lower urinary tract symptoms: a systematic review and meta-analysis.
Synthesis in Prostate cancer and prostatic diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Efficacy and Safety ofNutrients · 2026Trial
- Neurogenic gastrointestinal, urinary, and sexual dysfunction in multiple sclerosis: a multidisciplinary framework for clinical practice.The Lancet regional health. Europe · 2026Review
- Urinary Dysfunction in Myasthenic Syndromes: A Scoping Review of Clinical Features and Treatment-Related Associations.Muscle & nerve · 2026Article
- Mesenchymal stem Cells and Extracellular Vesicles in Bladder Dysfunction: Mechanisms and Translational Perspectives.Stem cell reviews and reports · 2026Review
- Counseling is counseling is counseling is counseling - The evolution of LUTS/BPO care.Prostate cancer and prostatic diseases · 2026Review
- Developmental exposure to a human-relevant PCB mixture: impacts on PCB congeners, metabolites, and drug-metabolizing enzymes in the bladder of post-weaning mice.Archives of toxicology · 2026Article
- Lower Urinary Tract Symptoms and Cognitive Impairment Among Participants in the REGARDS Cohort Study.Journal of the American Geriatrics Society · 2026Article
- Lower Urinary Tract Symptoms as an Indicator of Occult Neurologic Disease: A System-first Framework for Urologic Practice.Current urology reports · 2026Review
- Male Pelvic Health in Saudi Arabia:Saudi medical journal · 2026Article
- Symptoms and subtypes of patients with lower urinary tract dysfunction - insights from the Symptoms of Lower Urinary Tract Dysfunction Research Network.Nature reviews. Urology · 2026Review
- PCB Exposure in Adult Male Mice Reduces Proliferating Cells in the Prostate but Minimally Alters Voiding.Toxics · 2026Article
- Review
- The Bladder as a Target for PCB Toxicity: Evidence from PCB Levels, Phase I Metabolite Levels, and Cytochrome P450 Expression Following Developmental Exposure to a Human-Relevant PCB Mixture in Mice.Chemical research in toxicology · 2026Article
- Analysis of functional urological surgery trends 2013-2024 in England using the HES database.World journal of urology · 2026Article
- Accuracy of large language models in answering urological questions on lower urinary tract symptoms: comparison with the EAU 2025 guidelines.Central European journal of urology · 2026Article
- Identification and validation of genes associated with mitochondria in cerebral infarction and benign prostatic hyperplasia.Frontiers in medicine · 2026Article
- Smooth muscle of the lower urinary tract: BK-RyR coupling in physiology and pathophysiology.Journal of muscle research and cell motility · 2025Review
- Efficacy of Transurethral Resection of the Prostate in Male Patients With Impaired Detrusor Contractile Function and Urinary Retention.Lower urinary tract symptoms · 2025Article
- Tackling the progression of benign prostatic hyperplasia/benign prostatic obstruction progression: Deobstructing within the "window of curability" (a hypothesis-generating review).Current urology · 2025Article
- The Design and Application of Wearable Ultrasound Devices for Detection and Imaging.Biosensors · 2025Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLower urinary tract symptoms (LUTS) are common complaint in urology practice and affecting the quality of life for patients. This article aims to perform a systematic review and meta-analysis on the global prevalence of LUTS overall, and according to different patient characteristics.
methodsWe searched MEDLINE and Embase for population-based epidemiological studies reporting the prevalence of LUTS from inception to 1 Jan 2021. Studies which: (1) have enough information on sample size and prevalence; (2) investigate individuals aged 15 or above; and (3) have clear diagnostic criteria for LUTS. We extracted the following information: year of publication; name of the first author; study period; region of recruitment; race; age range; sex; severity; symptoms; and criteria. We pooled rate estimates with exact binomial and test score-based confidence intervals (CIs) using proportions with a random-effects model.
resultsWe included 222 studies from 36 countries involving 1,692,110 samples and 632,933 patients with LUTS. The overall prevalence of any and moderate-to-severe LUTS was 63.2% (95% CI = 58.0-68.1) and 31.3% (95% CI = 28.8-33.8), respectively. The most common symptom was storage symptoms (56.7%; 95% CI = 51.0-62.4), followed by voiding symptoms (36.4%; 95% CI = 27.8-45.4) and post-micturition symptoms (30.7%; 95% CI = 19.2-43.6). A higher prevalence of moderate-to-severe LUTS was observed in male subjects (35.2%; 95% CI = 32.1-38.5) and individuals aged ≥60 (39.0%; 95% CI = 33.4-44.8; I
conclusionsThis study was the first comprehensive meta-analysis examining the global prevalence of LUTS. We identified a high level of LUTS prevalence in the general population, with a higher burden in male subjects, older individuals, and the Asian population. There has been an increasing trend in the prevalence of LUTS since the 1990s.
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Registered trials
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