Evidence map›Paper›PMID 36414775›Full record

Trial reportAIDS and behavior2023

Contingency Management for Integrated Harm Reduction Among Men Who Have Sex with Men Who Use Methamphetamine in Los Angeles: A Pilot Assessment.

Cheríe S Blair, Monica Gandhi, Steven Shoptaw, Christopher Blades, Jesse L Clark

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Cheríe S BlairDepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, CHS 52-215, 90095, Los Angeles, CA, USA. cherieblair@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-6535-0018
Monica GandhiDepartment of Medicine, Division of Infectious Diseases, University of California, San Francisco, CA, USA.
Steven ShoptawDepartment of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Christopher BladesDepartment of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jesse L ClarkDepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, CHS 52-215, 90095, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING-PUMA)R01AI143340 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2018 to 2026
$5.6M
Unraveling the intersection of substance use, inflammation, and HIV via hair levelsR01DA059291 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi, Pamina Mae Gorbach · 2023 to 2026
$3.0M
Effects of methamphetamine use on risk behavior, systemic and mucosal inflammation, and sexually transmitted infection (STI)/HIV risk among men who have sex with menK23DA054004 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLAIR, CHERIE SAVINE · 2021 to 2025
$1.0M
NIAID NIH HHS L30 AI147119NIAID NIH HHS R01 AI143340NIDA NIH HHS K23 DA054004NIDA NIH HHS R01 DA059291NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

Methamphetamine (MA) use is associated with HIV transmission among men who have sex with men (MSM) and lapses in medication adherence. Contingency Management (CM) is effective in reducing MA use, but studies of CM to support adherence to HIV prevention or treatment are limited. We conducted a pilot trial of a CM intervention to reduce MA use and improve PrEP/ART adherence among MSM prescribed a tenofovir (TFV)-based regimen for HIV prevention or treatment. Participants were randomly assigned to receive escalating incentives for either MA abstinence or TFV adherence (based on point-of-care urine testing), and to a monitoring schedule of either 2 or 3 visits/week for 4 weeks. 19 MSM were randomized to either CM for MA use or CM for PrEP/ART adherence (median age: 38; IQR: 28-46) and 15 were living with HIV. Participants attended 95.7% (67/70) of scheduled visits in the 2x/week arm and 74.8% (74/99) in the 3x/week arm. TFV adherence was higher among participants in the TFV adherence arm with 93.5% (n = 72/77) of urine samples positive for TFV, compared to 76.6% (n = 49/64) in the MA abstinence arm (p = 0.007). Participants in the MA abstinence arm had more urine samples negative for MA metabolites (20.3%, n = 13/64) than those receiving CM for TFV adherence (6.5%, n = 5/77; p = 0.021). A CM model for MA abstinence and PrEP/ART adherence using twice-weekly visits and urine testing for MA and TFV for MSM who use MA is feasible and potentially effective as an integrated harm reduction strategy.

Indexed as

Anti-HIV AgentsHIV InfectionsMethamphetaminePre-Exposure ProphylaxisSexual and Gender MinoritiesAdultHarm ReductionHomosexuality, MaleHumansLos AngelesMaleMedication AdherenceTenofovirAnti-HIV AgentsMethamphetamineTenofoviradherencecontingency managementmen who have sex with menstimulant usesubstance use

Identifiers

PMID36414775
PMCPMC10152513
OpenAlexW4309651024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.