ArticleCommunications biology2022
Brain sex-dependent alterations after prolonged high fat diet exposure in mice.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Olfactory dysfunction in obesity and type 2 diabetes: mechanistic insights from preclinical models.Diabetologia · 2026Review
- Effects of Maternal Obesity on Fetal Cerebral Glucose Transporter Expression.bioRxiv : the preprint server for biology · 2026Article
- Neurobiology of co-morbid stress and a western diet in mice: mitochondrial, proteomic and behavioral outcomes.Metabolic brain disease · 2026Article
- STAT4-dependent regulation of neuroinflammation in atherosclerosis.Physiological reports · 2026Article
- GPR75 in glutamatergic neurons regulates body weight.Cell reports · 2026Article
- STAT4-dependent regulation of neuroinflammation in atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Optimization and verification of high-fat diet formulation for establishing a rat model of obesity-related precocious puberty.Animal models and experimental medicine · 2026Article
- High-saturated-fat diet drives female-biased neurodegeneration inFrontiers in aging neuroscience · 2026Article
- Aging reveals divergent responses of AgRP/NPY neurons to diet in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Sex-dependent effects of a high-fat diet-induced obesity model on cerebrovascular health and brain metabolism.Experimental physiology · 2025Article
- Obesity drives temporally distinct physical activity disruptions in mice under a fixed 24-h light-dark cycle.Scientific reports · 2025Article
- Ceruloplasmin administration in the preclinical mouse model of aceruloplasminemia reveals a sex-related variation in biodistribution.Communications biology · 2025Article
- Autophagy across tissues of aging mice.PloS one · 2025Article
- Acute elevated dietary fat alone is not sufficient to decrease AgRP projections in the paraventricular nucleus of the hypothalamus in mice.Scientific reports · 2024Article
- High fat diet affects the hippocampal expression of miRNAs targeting brain plasticity-related genes.Scientific reports · 2024Article
- Preventing High Fat Diet-Induced Obesity and Related Hepatic Steatosis by Chlorin e6-Mediated Photodynamic Therapy.Pharmaceuticals (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined effects of exposing female and male mice for 33 weeks to 45% or 60% high fat diet (HFD). Males fed with either diet were more vulnerable than females, displaying higher and faster increase in body weight and more elevated cholesterol and liver enzymes levels. Higher glucose metabolism was revealed by PET in the olfactory bulbs of both sexes. However, males also displayed altered anterior cortex and cerebellum metabolism, accompanied by a more prominent brain inflammation relative to females. Although both sexes displayed reduced transcripts of neuronal and synaptic genes in anterior cortex, only males had decreased protein levels of AMPA and NMDA receptors. Oppositely, to anterior cortex, cerebellum of HFD-exposed mice displayed hypometabolism and transcriptional up-regulation of neuronal and synaptic genes. These results indicate that male brain is more susceptible to metabolic changes induced by HFD and that the anterior cortex versus cerebellum display inverse susceptibility to HFD.
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