Evidence map›Paper›PMID 36414650›Full record

ArticleScientific reports2022

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality.

Alisia Madè, Simona Greco, Melanie Vausort, Marios Miliotis, Eric Schordan, Shounak Baksi, Lu Zhang, Ekaterina Baryshnikova, Marco Ranucci, Rosanna Cardani and 8 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 5 countries.

Alisia MadèMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, MI, Italy.
Simona GrecoMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, MI, Italy.ORCID 0000-0002-0275-7221
Melanie VausortCardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1445, Strassen, Luxembourg.
Marios MiliotisHellenic Pasteur Institute, 11521, Athens, Greece.
Eric SchordanFiralis SA, 35 Rue du Fort, 68330, Huningue, France.
Shounak BaksiCardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1445, Strassen, Luxembourg.
Lu ZhangBioinformatics Platform, Luxembourg Institute of Health, L-1445 Strassen, Luxembourg.
Ekaterina BaryshnikovaDepartment of Cardiovascular Anesthesia and ICU, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, MI, Italy.
Marco RanucciDepartment of Cardiovascular Anesthesia and ICU, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, MI, Italy.
Rosanna CardaniBioCor Biobank, UOC SMEL-1 of Clinical Pathology, Department of Pathology and Laboratory Medicine, IRCCS-Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, MI, Italy.
Guy FagherazziDeep Digital Phenotyping Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1 A-B Rue Thomas Edison, 1445, Strassen, Luxembourg.
Markus OllertDepartment of Infection and Immunity, Luxembourg Institute of Health, 29, Rue Henri Koch, 4354, Esch-Sur-Alzette, Luxembourg.
Spyros TastsoglouHellenic Pasteur Institute, 11521, Athens, Greece.ORCID 0000-0002-0316-6239
Giannis VatsellasGreek Genome Center, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece.
Artemis HatzigeorgiouHellenic Pasteur Institute, 11521, Athens, Greece.
Hüseyin FiratFiralis SA, 35 Rue du Fort, 68330, Huningue, France.
Yvan DevauxCardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, 1445, Strassen, Luxembourg. yvan.devaux@lih.lu.
Fabio MartelliMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, MI, Italy. fabio.martelli@grupposandonato.it.ORCID 0000-0002-8624-7738
IRCCS Policlinico San Donato · ITLuxembourg Institute of Health · LUUniversity of Thessaly · GRFiralis (France) · FRAcademy of Athens · GRUniversity of Southern Denmark · DK

Funding

EC | European Regional Development Fund (Europski Fond za Regionalni Razvoj) FEDER, 2018-04-026-21EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101016072EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) CA17129Fondazione Telethon (Telethon Foundation) 4462 GGP19035AFonds National de la Recherche Luxembourg (National Research Fund) 14716273Fonds National de la Recherche Luxembourg (National Research Fund) COVID-19/2020-1/14719577/miRCOVIDMinistero della Salute (Ministry of Health, Italy) RF-2019-12368521
6 · The paper itself

Abstract

Coronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition and predicting clinical outcome. Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR-144-3p was dynamically regulated in response to COVID-19. Thus, we further investigated the biomarker potential of miR-144-3p measured at admission in 179 COVID-19 patients and 29 healthy controls recruited in three centers. In hospitalized patients, circulating miR-144-3p levels discriminated between non-critical and critical illness (AUC

Indexed as

COVID-19MicroRNAsBiomarkersEpidermal Growth FactorHumansInterleukin-10BiomarkersEpidermal Growth FactorInterleukin-10MicroRNAsMIRN144 microRNA, human

Identifiers

PMID36414650
PMCPMC9681736
OpenAlexW4309650835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.