Evidence map›Paper›PMID 36414535›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023

Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity.

Kerem C Gurol, Danyang Li, Karin Broberg, Somshuvra Mukhopadhyay

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. PHD2 enzyme is an intracellular manganese sensor that initiates the homeostatic response against elevated manganese.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kerem C GurolDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas.
Danyang LiDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas.
Karin BrobergDivision of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Somshuvra MukhopadhyayDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas.ORCID 0000-0002-3420-7830
The University of Texas at Austin · USLund University · SE

Funding

Role and mechanisms of excretion in manganese neurotoxicityR01ES031574 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI MUKHOPADHYAY, SOMSHUVRA · 2020 to 2025
$3.5M
NIEHS NIH HHS R01 ES031574
6 · The paper itself

Abstract

The activity of the manganese (Mn) efflux transporter SLC30A10 in the liver and intestines is critical for Mn excretion and preventing Mn toxicity. Homozygous loss-of-function mutations in

Indexed as

Cation Transport ProteinsManganeseBiological TransportHumansLiverMutationCation Transport ProteinsManganeseSLC30A10 protein, humanexcretionhomeostasismetaltransporterZnT10

Identifiers

PMID36414535
PMCPMC9829465
OpenAlexW4309682437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.