Observational studyNeurology2023
Association Between Net Water Uptake and Functional Outcome in Patients With Low ASPECTS Brain Lesions: Results From the I-LAST Study.
Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04862507 (Improving Low Alberta Stroke Program Early ct Score Stroke Thrombectomy), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Low Alberta Stroke Program Early ct Score Stroke Thrombectomy
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neuroimaging predictors of malignant brain oedema after thrombectomy in ischemic stroke: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Endovascular thrombectomy with or without intravenous alteplase in large-core ischemic stroke: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Net water uptake as a predictive neuroimaging marker for acute ischemic stroke outcomes: a meta-analysis.European radiology · 2024Pooled it
- Association of 24-Hour Computed Tomography Infarct Density on Functional Outcomes in Stroke: Secondary Analysis From the AcT Trial.Journal of the American Heart Association · 2026Trial
- Oedema reduction mediates thrombectomy benefit in large core stroke: secondary analysis of the TENSION trial.European stroke journal · 2026Trial
- Tmax 10 Volume Is Independently Associated with NWU Delta in Large Core Stroke.Clinical neuroradiology · 2026Observational
- Clinical evaluation of an automated Alberta Stroke Program Early Computed Tomography Score (ASPECTS)-scoring system.Quantitative imaging in medicine and surgery · 2026Article
- Mediation of ghost infarct core on prognosis by venous outflow and net water uptake after stroke thrombectomy.European radiology · 2026Article
- Fully automated quantification of net water uptake in acute ischemic stroke using only non-contrast CT imaging.European radiology · 2026Article
- Using NIRS-Based Spectroscopy for the Comparison of Cerebral Net-Water Uptake and Microcirculation in Posttraumatic Penumbra in Severe Traumatic Brain Injury Patients.Academic radiology · 2026Article
- Clinical Benefit of Thrombectomy in Large-Core Infarction Patients Is Mediated by Malignant Cerebral Edema Reduction.Journal of the American Heart Association · 2026Article
- Sex Differences in Prognostic Markers: Exploring Outcome Variability After Mechanical Thrombectomy in Large Vessel Occlusion Stroke.Journal of clinical medicine · 2025Article
- Predicting futile recanalization before mechanical thrombectomy: the added value of CT imaging markers.Neuroradiology · 2025Article
- Large Core Trial.AJNR. American journal of neuroradiology · 2025Review
- Net water uptake combined with neutrophil-to-lymphocyte ratio predictive value after successful recanalization in acute large vessel occlusion stroke.Frontiers in neurology · 2025Article
- Current perspective in acute ischemic stroke: net water uptake and imaging-guided selection as bridges to personalized, tissue-based care.Frontiers in neurology · 2025Article
- Editorial: Novel approaches in diagnosis and management of ischemic edema in large vessel occlusion stroke, volume II.Frontiers in neurology · 2025Article
- Deep learning biomarker of chronometric and biological ischemic stroke lesion age from unenhanced CT.NPJ digital medicine · 2024Article
- Role of Computed Tomography Angiography Enhancement Ratio in Predicting Prognosis in Patients With Stroke Undergoing Endovascular Treatment.Stroke (Hoboken, N.J.) · 2024Article
- Automated Prediction of Proximal Middle Cerebral Artery Occlusions in Noncontrast Brain Computed Tomography.Stroke · 2024Article
Corrections and comments
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Authors and funding
23 authors.
Gabriel BroocksFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany. g.broocks@uke.de.
Lukas MeyerFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Sarah ElsayedFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Rosalie McDonoughFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Matthias BechsteinFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Tobias Djamsched FaizyFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Peter SpornsFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Gerhard SchönFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.ORCID 0000-0003-2556-6804
Jens MinnerupFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Helge C KniepFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Uta HanningFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Ewgenia BarowFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Peter SchrammFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Soenke LangnerFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Jawed NawabiFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Panagiotis PapanagiotouFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Max WintermarkFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Maarten G LansbergFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.ORCID 0000-0002-3545-6927
Gregory W AlbersFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
Jeremy J HeitFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.ORCID 0000-0003-1055-8000
Jens FiehlerFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.ORCID 0000-0001-8533-7478
Andre KemmlingFrom the Departments of Diagnostic and Interventional Neuroradiology (G.B., L.M., S.E., R.M., M.B., T.D.F., P. Sporns, H.C.K., U.H., J.F.) and Neuroradiology (S.L.), and Institute of Medical Biometry and Epidemiology (G.S.), University Medical Center Hamburg-Eppendorf, Germany; Departments of Clinical Neuroscience and Radiology (R.M.), Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Alberta, Canada; Department of Neuroradiology (T.D.F.), Stanford University, CA; Department of Neuroradiology (P. Sporns), Universitätsspital Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (J.M.), University Hospital Münster; Department of Neuroradiology (P. Schramm), University Hospital Schleswig-Holstein, Luebeck; Department of Neuroradiology (S.L.), University Greifswald; Department of Neuroradiology (S.L.), University Medical Center Rostock; Department of Neuroradiology (J.N.), Charité University Medicine, Berlin; Department of Neuroradiology (P.P.), Hospital Bremen-Mitte, Germany; Department of Neuroradiology (M.W.), MD Anderson, Houston, TX; Departments of Neurology and Neurological Sciences (M.G.L., G.W.A.) and Radiology (J.J.H.), Stanford University School of Medicine, CA; and Department of Neuroradiology (A.K.), University Hospital Marburg, Germany.
I-LAST Investigators
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe effect of mechanical thrombectomy (MT) on functional outcome in patients with ischemic stroke with low ASPECTS is still uncertain. ASPECTS rating is based on the presence of ischemic hypoattenuation relative to normal; however, the degree of hypoattenuation, which directly reflects net uptake of water, is currently not considered an imaging biomarker in stroke triage. We hypothesized that the effect of thrombectomy on functional outcome in low ASPECTS patients depends on early lesion water uptake.
methodsFor this multicenter observational study, patients with anterior circulation stroke with ASPECTS ≤5 were consecutively analyzed. Net water uptake (NWU) was assessed as a quantitative imaging biomarker in admission CT. The primary end point was the rate of favorable functional outcome defined as modified Rankin Scale score 0-3 at day 90. The effect of recanalization on functional outcome was analyzed according to the degree of NWU within the early infarct lesion.
resultsA total of 254 patients were included, of which 148 (58%) underwent MT. The median ASPECTS was 4 (interquartile range [IQR] 3-5), and the median NWU was 11.4% (IQR 8.9%-15.1%). The rate of favorable outcome was 27.6% in patients with low NWU (<11.4%) vs 6.3% in patients with high NWU (≥11.4%; DISCUSSION: Early NWU was independently associated with clinical outcome and might serve as an indicator of futile MT in low ASPECTS patients. NWU could be tested as a tool to select low ASPECTS patients for MT. TRIAL REGISTRATION INFORMATION: The study is registered within the ClinicalTrials.gov Protocol Registration and Results System (NCT04862507).
Indexed as
Brain IschemiaStrokeBrainCerebral InfarctionHumansRetrospective StudiesThrombectomyTomography, X-Ray ComputedTreatment OutcomeWaterWater
Identifiers
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Registered trials
NCT04862507ClinicalTrials.gov
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