Evidence map›Paper›PMID 36414343›Full record

ArticleBMJ case reports2022

Pembrolizumab-induced acute right L5 neuritis unresponsive to steroids.

Lachlan Fitzpatrick, Zarnie Lwin, Christian Gericke

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Lachlan FitzpatrickInternal Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia lachlan.fitzpatrick@health.qld.gov.au.
Zarnie LwinMedical Oncology, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Christian GerickeThe University of Queensland Faculty of Medicine, Brisbane, Queensland, Australia.
Prince Charles Hospital · AURoyal Brisbane and Women's Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a patient with metastatic lung adenocarcinoma who developed severe right lower limb radicular pain in a L5-S1 dermatomal distribution 5 months into treatment with carboplatin, pemetrexed and pembrolizumab. MRI of the lumbar spine demonstrated contrast enhancement of the right L5 nerve root consistent with neuritis. The patient was treated with intravenous methylprednisolone 2 mg/kg/day for 3 days, followed by oral prednisolone 1 mg/kg/day with a slow wean over 6 weeks. There was no improvement and their performance status deteriorated to an Eastern Cooperative Oncology Group (ECOG) score of 3, representing capability of only limited self-care. We commenced induction therapy with intravenous immunoglobulin 2 g/kg over 5 days, which resulted in complete resolution of pain sustained for 3 weeks before recurrence of symptoms. We continued maintenance therapy with intravenous immunoglobulin 0.4 g/kg over 2 days at 4-5 weekly intervals, which led to resolution of symptoms and ECOG score to 1.

Indexed as

Immunoglobulins, IntravenousNeuritisAntibodies, Monoclonal, HumanizedHumansPainSteroidsAntibodies, Monoclonal, HumanizedImmunoglobulins, IntravenouspembrolizumabSteroidsLung cancer (oncology)NeurooncologyPeripheral nerve diseaseUnwanted effects / adverse reactions

Identifiers

PMID36414343
PMCPMC9685257
OpenAlexW4309592886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.