Evidence map›Paper›PMID 36414332›Full record

ArticleOpen heart2022

Comprehensive nationwide incidence and prevalence trends of atrial fibrillation in Finland.

Mika Lehto, Jari Haukka, Aapo Aro, Olli Halminen, Jukka Putaala, Miika Linna, Pirjo Mustonen, Janne Kinnunen, Elis Kouki, Jussi Niiranen and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04645537 (Finnish AntiCoagulation in Atrial Fibrillation), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04645537 completednot on this map

Finnish AntiCoagulation in Atrial Fibrillation (FinACAF)

TypeobservationalSponsorHelsinki University Central HospitalRan2011 to 2018Enrolled400,000ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  10. Adverse events after catheter ablation of atrial fibrillation: a comprehensive nationwide cohort study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
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  14. How much does elective cardioversion increase the risk of ischaemic stroke compared to the baseline risk in atrial fibrillation? A nationwide study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
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  17. Venous thromboembolisms and stroke risk in patients with atrial fibrillation: a nationwide cohort study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Mika LehtoDepartment of Internal Medicine, Jorvi Hospital, Espoo, Finland mika.lehto@hus.fi.ORCID 0000-0002-8691-5142
Jari HaukkaDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Aapo AroHeart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.
Olli HalminenDepartment of Industrial Engineering and Management, Aalto University, Espoo, Finland.ORCID 0000-0001-9266-8435
Jukka PutaalaDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Miika LinnaDepartment of Industrial Engineering and Management, Aalto University, Espoo, Finland.
Pirjo MustonenTYKS Turku University Hospital, Turku, Finland.
Janne KinnunenDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.ORCID 0000-0002-0592-3184
Elis KoukiUniversity of Helsinki, Medical Faculty, Helsinki, Finland.
Jussi NiiranenHeart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.
Alex LuojusHeart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.
Paula TiiliDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Saga Itäinen-StrömbergHeart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.
Juha HartikainenDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
Juhani K E AiraksinenTYKS Turku University Hospital, Turku, Finland.
FinACAF study group
Helsinki University Hospital · FITurku University Hospital · FIUniversity of Helsinki · FIAalto University · FIFlorida State University · USKuopio University Hospital · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAtrial fibrillation (AF) is a worldwide healthcare challenge owing to population ageing. In this study, we assessed the current trends in the incidence and prevalence of AF for the first time in an unselected, nationwide population.

methodsIn the Finnish Anticoagulation in Atrial Fibrillation study, we gathered comprehensive data including all primary, secondary and tertiary healthcare visits and drug reimbursement from national healthcare registers to identify all patients with incident AF between 2004 and 2018 in Finland. Incident AF was defined as new-onset AF occurring after 2007. Time trends for the incidence and prevalence of AF were calculated and stratified by sex and age.

resultsA total of 411 387 patients with AF diagnosis were documented in Finland during 2004-2018. In 2018, the incidence and prevalence of AF in the total Finnish population were 469/100 000 and 4.1%, respectively. The incidence of new-onset AF in the adult population (≥20 years) increased from 471/100 000 in 2007 to 604/100 000 in 2018, but the age-adjusted incidence remained stable. The prevalence of AF increased in the adult population from 2.5% to 5.2%, and was higher in men than in women (5.9% vs 4.6%, p<0.001). The incidence and prevalence of AF increased with age and were 3194/100 000 and 23.4% in patients older than 75 years.

conclusionsBased on comprehensive nationwide data including primary care, we observed an increasing incidence and prevalence of AF over time. This increase was strongly age-dependent with the age-standardised incidence remaining stable during 2007-2018. TRIAL REGISTRATION NUMBER: NCT04645537.

Indexed as

Atrial FibrillationAdultAgingFemaleFinlandHumansIncidenceMalePrevalenceAtrial FibrillationEpidemiologyHealth Care Economics and Organizations

Identifiers

PMID36414332
PMCPMC9685262
OpenAlexW4309592844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.