Evidence map›Paper›PMID 36414265›Full record

ArticleACS chemical biology2022

Multivalent Fucosides Targeting β-Propeller Lectins from Lung Pathogens with Promising Anti-Adhesive Properties.

Margherita Duca, Diksha Haksar, Jacq van Neer, Dominique M E Thies-Weesie, Dania Martínez-Alarcón, Hans de Cock, Annabelle Varrot, Roland J Pieters

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Margherita DucaDepartment of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, NL-3508 TB Utrecht, The Netherlands.
Diksha HaksarDepartment of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, NL-3508 TB Utrecht, The Netherlands.
Jacq van NeerDepartment of Biology, Utrecht University, Padualaan 8, 3584 CS Utrecht, The Netherlands.
Dominique M E Thies-WeesieDebye Institute for Nanomaterials Science, Utrecht University, Padualaan 8, 3584 CS Utrecht, The Netherlands.
Dania Martínez-AlarcónUniv. Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.
Hans de CockDepartment of Biology, Utrecht University, Padualaan 8, 3584 CS Utrecht, The Netherlands.
Annabelle VarrotUniv. Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.ORCID 0000-0001-6667-8162
Roland J PietersDepartment of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, NL-3508 TB Utrecht, The Netherlands.ORCID 0000-0003-4723-3584
Utrecht University · NLCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal and bacterial pathogens causing lung infections often use lectins to mediate adhesion to glycoconjugates at the surface of host tissues. Given the rapid emergence of resistance to the treatments in current use, β-propeller lectins such as FleA from

Indexed as

AdhesivesLectinsAspergillus fumigatusFucoseHumansLungAdhesivesFucoseLectins

Identifiers

PMID36414265
PMCPMC9764287
OpenAlexW4309672868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.