ArticleCellular and molecular gastroenterology and hepatology2023
Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium Is Regulated by Sprouty2 and Interleukin 13.
Article in Cellular and molecular gastroenterology and hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- Context-dependent roles of resistin-like molecule β in mucosal defense and inflammatory diseases.Frontiers in immunology · 2026Review
- Intestinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD.Stem cell research & therapy · 2025Article
- Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell.Cell stem cell · 2025Article
- Enterocloster clostridioformis protects against Salmonella pathogenesis and modulates epithelial and mucosal immune function.Microbiome · 2025Article
- Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis.Mucosal immunology · 2025Article
- Deep crypt secretory cells shape region-specific mucin glycosylation patterns in the mouse colon.PloS one · 2025Article
- Crosstalk ofOncoTargets and therapy · 2025Article
- Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience.Discovery immunology · 2025Article
- BEST4American journal of physiology. Cell physiology · 2024Review
- Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids.Cell death & disease · 2024Article
- SLE serum induces altered goblet cell differentiation and leakiness in human intestinal organoids.EMBO molecular medicine · 2024Article
- Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis.Frontiers in cellular and infection microbiology · 2024Review
- The emerging roles of deep crypt secretory cells in colonic physiology.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Expression Profiling along the Murine Intestine: Different Mucosal Protection Systems and Alterations inInternational journal of molecular sciences · 2023Article
- Sonic Hedgehog: Powering up Intestinal Regeneration?Cellular and molecular gastroenterology and hepatology · 2023Article
- Re-evaluating the Role of Deep Crypt Secretory Cells in Intestinal Homeostasis.Cellular and molecular gastroenterology and hepatology · 2023Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsDeep crypt secretory (DCS) cells are a critical component of the colonic stem cell niche. However, the regulatory mechanisms controlling DCS cell numbers and function are not well understood. Sprouty2 is an inflammation-responsive regulator of intracellular signaling that influences colonic secretory cell numbers in colitis via an epithelial-stromal interleukin (IL)33/IL13 signaling loop. Here, we tested the hypothesis that IL13, induced by epithelial Sprouty2 down-regulation, promotes DCS cell differentiation and function.
methodsDistal colons from mice with an intestinal epithelial-specific Sprouty2 deletion (Spry2
resultsReg4
conclusionsSprouty2 limits colonic DCS cell differentiation through suppression of IL13 signaling. At homeostasis, DCS cells are marked by high levels of the HDP RELMβ. Loss of epithelial Sprouty2 activates type II innate lymphoid cells to release IL13, promoting expansion of the DCS cell population and increased colonic RELMβ levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.