ArticleClinical biochemistry2023
Performance of glycated albumin as a biomarker of hyperglycemia in pregnancy: Results from the National Health and Nutrition Examination Survey 1999-2004.
Article in Clinical biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Performance of flash continuous glucose monitoring and glycemic marker correlations in Chinese pregnant women with non-type 1 diabetes.World journal of diabetes · 2025Article
- Role of random blood glucose and HbA1c levels in optimizing glucose tolerance screening in early pregnancy: a retrospective cohort study.Obstetrics & gynecology science · 2025Article
- Association of Overnight Fasting Duration and Meal Frequency with Glucose and Lipid Metabolism During Pregnancy: A Cross-Sectional Study.Nutrients · 2025Article
- Glycated albumin in pregnancy correlates negatively with body mass index and contributes to the risk of gestational diabetes mellitus.Practical laboratory medicine · 2024Article
- Glycolaldehyde-derived advanced glycation end products promote macrophage proliferation via the JAK-STAT signaling pathway.Molecular biology reports · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
aimWe sought to evaluate the performance of glycated albumin (GA) as a measure of hyperglycemia in pregnant women.
methodsWe used data from 555 pregnant women aged 20-40 years who participated in NHANES 1999-2004 and did not report a pre-pregnancy diagnosis of diabetes. We used Pearson's correlations and evaluated the area under the curve (AUC) for GA to detect elevated concentrations of random glucose, HbA1c, or fasting glucose (subset). We compared results to 1607 nonpregnant women aged 20-40 without diabetes.
resultsIn pregnant women, 1.9 % had HbA1c ≥ 39 mmol/mol (≥5.7 %), 9.1 % had random glucose ≥ 5.3 mmol/L (≥95 mg/dL), and 10.7 % had fasting glucose ≥ 5.3 mmol/L. In pregnancy, GA was poorly correlated with HbA1c (r = 0.08) and random glucose (r = 0.17). BMI was positively associated with HbA1c (r = 0.33) and random glucose (r = 0.25) but was inversely associated with GA (r = -0.27). GA had poor discrimination for detecting hyperglycemia in pregnant women, defined as HbA1c ≥ 39 mmol/mol (AUC = 0.634) or random glucose ≥ 5.3 mmol/L (AUC = 0.628). Similar patterns were observed among nonpregnant women.
conclusionsGA is not a sensitive test to screen for hyperglycemia in pregnancy. GA was inversely associated with adiposity in pregnant women without diabetes. Pregnancy-related weight gain may complicate interpretation of repeated GA measurements.
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