Evidence map›Paper›PMID 36414008›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Endogenous PTEN-Induced Kinase 1 Regulates Dendritic Architecture and Spinogenesis.

P Anthony Otero, Gabriella Fricklas, Aparna Nigam, Britney N Lizama, Zachary P Wills, Jon W Johnson, Charleen T Chu

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Rethinking 'rare'Journal of Parkinson's disease · 2025
    Pooled it
  2. Review
  3. Article
  4. Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

P Anthony OteroDepartment of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Gabriella FricklasDepartment of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Aparna NigamDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Britney N LizamaDepartment of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.ORCID https://orcid.org/0000-0001-5970-3913
Zachary P WillsDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.ORCID https://orcid.org/0000-0001-9822-6742
Jon W JohnsonDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.ORCID https://orcid.org/0000-0001-5085-3296
Charleen T ChuDepartment of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 ctc4@pitt.edu.ORCID https://orcid.org/0000-0002-5052-8271
University of Pittsburgh · US

Funding

Regulation of Autophagy & Mitochondrial Recycling in Neuronal Cell Death- SupplementR01AG026389 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, CHARLEEN T · 2007 to 2024
$6.0M
Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBD Diversity SupplementR01NS101628 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Charleen T Chu, Zachary P Wills · 2017 to 2026
$4.0M
Ca2+-Dependent Block by Mematine and Selective Inhibition of Overactive NMDA ReceptorsR01AG065594 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, JON W. · 2020 to 2024
$2.8M
PINK1 regulates cytoplasmic dynein and mitochondrial transportF31NS108504 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OTERO, PETER ANTHONY · 2019 to 2021
$90k
PINK1 protects neurons against mutant Tau pathologyF32AG069343 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIZAMA, BRITNEY NOLA · 2020 to 2020
$68k
NIA NIH HHS F32 AG069343NIA NIH HHS R01 AG026389NIA NIH HHS R01 AG065594NINDS NIH HHS F31 NS108504NINDS NIH HHS R01 NS101628NINDS NIH HHS T32 NS086749
6 · The paper itself

Abstract

Mutations in PTEN-induced kinase 1 (PINK1) contribute to autosomal recessive Parkinson's disease with cognitive and neuropsychiatric comorbidities. Disturbances in dendritic and spine architecture are hallmarks of neurodegenerative and neuropsychiatric conditions, but little is known of the impact of PINK1 on these structures. We used

Indexed as

Dendritic SpinesParkinson DiseaseAnimalsHumansMiceNeuronsPhosphorylationProtein KinasesPTEN PhosphohydrolaseProtein KinasesPTEN PhosphohydrolasePTEN protein, humancortical neurondementiadendritic architecturedendritic spinesNSFL1CPTEN-induced kinase 1

Identifiers

PMID36414008
PMCPMC9581559
OpenAlexW4294884819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.