Evidence map›Paper›PMID 36413975›Full record

ArticleACS chemical biology2022

Inhibition and Mechanism of

Yacoba V T Minnow, Kajitha Suthagar, Keith Clinch, Rodrigo G Ducati, Agnidipta Ghosh, Joshua N Buckler, Rajesh K Harijan, Sean M Cahill, Peter C Tyler, Vern L Schramm

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yacoba V T MinnowDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Kajitha SuthagarFerrier Research Institute, Victoria University of Wellington, Gracefield, Lower Hutt 5010, New Zealand.
Keith ClinchFerrier Research Institute, Victoria University of Wellington, Gracefield, Lower Hutt 5010, New Zealand.
Rodrigo G DucatiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0002-8783-8847
Agnidipta GhoshDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Joshua N BucklerFerrier Research Institute, Victoria University of Wellington, Gracefield, Lower Hutt 5010, New Zealand.ORCID 0000-0002-4397-9947
Rajesh K HarijanDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Sean M CahillDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0003-2877-0704
Peter C TylerFerrier Research Institute, Victoria University of Wellington, Gracefield, Lower Hutt 5010, New Zealand.ORCID 0000-0002-3151-6208
Vern L SchrammDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0002-8056-1929
Albert Einstein College of Medicine · USVictoria University of Wellington · NZ

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSR01GM041916 · NIGMS · YESHIVA UNIVERSITY · PI SCHRAMM, VERN L. · 1989 to 2023
$10.0M
PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASER01AI127807 · NIAID · TEXAS A&M AGRILIFE RESEARCH · PI MEEK, THOMAS, SCHRAMM, VERN L. · 2017 to 2021
$5.2M
Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONSR37GM041916 · NIGMS · YESHIVA UNIVERSITY · PI SCHRAMM, VERN L. · 1998 to 2007
$3.5M
An integrated X-ray data collection systemS10OD020068 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMO, STEVEN C. · 2015 to 2015
$600k
Console and probe upgrade for 600 MHz NMRS10OD016305 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI COWBURN, DAVID · 2014 to 2014
$595k
NCI NIH HHS P30 CA013330NIAID NIH HHS R01 AI127807NIAID NIH HHS T32 AI070117NIGMS NIH HHS R01 GM041916NIGMS NIH HHS R37 GM041916NIH HHS S10 OD016305NIH HHS S10 OD020068
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DiphosphatesPlasmodium falciparumHypoxanthinesIsotopesKineticsOxygenPentosyltransferasesDiphosphatesdiphosphoric acidhypoxanthine-guanine-xanthine phosphoribosyltransferaseHypoxanthinesIsotopesOxygenPentosyltransferases

Identifiers

PMID36413975
PMCPMC9772100
OpenAlexW4309647518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.