ArticleDevelopmental cell2022
Autophagy promotes cell survival by maintaining NAD levels.
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Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41citing papers in PubMed, 1 pooled it
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41 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- NADFrontiers in neurology · 2026Pooled it
- Protocol for analyzing autophagy-related cellular phenotypes in autophagy-deficient human embryonic stem cell-derived lacrimal gland-like organoids.STAR protocols · 2026Article
- Drugging small-molecule compounds in autophagy-dependent cell death to overcome cancer therapy resistance.Apoptosis : an international journal on programmed cell death · 2026Review
- Activation of pro-survival autophagy by a small molecule promoting p62 oligomerization.The Journal of biological chemistry · 2026Article
- Selenium-Loaded Calcium Phosphate with Long-Term and Curative Dosage Drug Release for Post-Surgical Osteosarcoma Management and Osteogenesis.International journal of molecular sciences · 2026Article
- Enhanced anti-tumor effects of Imatinib and immune checkpoint inhibitors on gastrointestinal stromal tumor cells (GISTs): insights from monoculture and 3D co-culture models.Medical oncology (Northwood, London, England) · 2026Article
- Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress.Nature communications · 2026Article
- Longitudinal Transcriptomic Analysis Reveals Systemic Effects of Risdiplam in Adults with Spinal Muscular Atrophy.Brain sciences · 2026Article
- Anhydrobiosis as a Model of Aging and Longevity: The Role of Autophagy and Metabolism in Yeast Cells.Microbial ecology · 2026Review
- Autophagy is required for the development and functionality of lacrimal gland-like organoids.Stem cell reports · 2026Article
- From autophagy-lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders.Frontiers in neuroscience · 2026Review
- Sirtuins in mitophagy: key gatekeepers of mitochondrial quality.Molecular and cellular biochemistry · 2025Review
- The lysosomal catabolism of nucleic acids-critical regulators of the innate immune system.Nucleic acids research · 2025Review
- MiR-148a-3p/SIRT7 axis promotes glioma progression and regulates temozolomide chemosensitivity.Journal of neuro-oncology · 2025Article
- BCL11A deficiency protects epidermis from UVB-induced damage through promotion of autophagy.Communications biology · 2025Article
- NADCells · 2025Review
- Mitochondrial complex I deficiency induces Alzheimer's disease-like signatures that are reversible by targeted therapy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Autophagy-NADFrontiers in molecular biosciences · 2025Review
- Targeting autophagy promotes the antitumor effect of radiotherapy on cervical cancer cells.Cancer biology & therapy · 2024Article
- Increased DNA damage in full-grown oocytes is correlated with diminished autophagy activation.Nature communications · 2024Article
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Authors and funding
31 authors at 13 institutions in 6 countries.
Tetsushi KatauraBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK; Department of Biosciences and Informatics, Keio University, Yokohama, Kanagawa 223-8522, Japan; Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo 113-8421, Japan.
Lucia SedlackovaBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Elsje G OttenBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Ruchika KumariAutophagy lab, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore 560064, India.
David ShapiraBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Filippo ScialoBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Rhoda StefanatosBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Kei-Ichi IshikawaDepartment of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo 113-8421, Japan; Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan.
George KellyBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Elena SeranovaInstitute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Congxin SunInstitute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Dorothea MaetzelWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Niall KennethInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK.
Sergey TrushinDepartment of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Tong ZhangInstitute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK; Novartis Institutes for Biomedical Research, Shanghai, China.
Eugenia TrushinaDepartment of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Charles C BascomThe Procter & Gamble Company, Cincinnati, OH 45040, USA.
Ryan TasseffThe Procter & Gamble Company, Cincinnati, OH 45040, USA.
Robert J IsfortThe Procter & Gamble Company, Cincinnati, OH 45040, USA.
John E OblongThe Procter & Gamble Company, Cincinnati, OH 45040, USA.
Satomi MiwaBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Michael LazarouDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Rudolf JaenischWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Masaya ImotoDepartment of Biosciences and Informatics, Keio University, Yokohama, Kanagawa 223-8522, Japan; Division for Development of Autophagy Modulating Drugs, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan.
Shinji SaikiDepartment of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo 113-8421, Japan; Division for Development of Autophagy Modulating Drugs, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan.
Manolis Papamichos-ChronakisInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK.
Ravi ManjithayaAutophagy lab, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore 560064, India.
Oliver D K MaddocksInstitute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.
Alberto SanzSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Sovan SarkarInstitute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: s.sarkar@bham.ac.uk.
Viktor I KorolchukBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK. Electronic address: viktor.korolchuk@newcastle.ac.uk.
Newcastle University · GBProcter & Gamble (United States) · USUniversity of Birmingham · GBJawaharlal Nehru Centre for Advanced Scientific Research · INJuntendo University · JPKeio University · JPMayo Clinic · USUniversity of Glasgow · GBUniversity of Liverpool · GBWhitehead Institute for Biomedical Research · USNovartis (China) · CNWalter and Eliza Hall Institute of Medical Research · AUWellcome Centre for Mitochondrial Research · GB
Funding
In Vitro Reprogramming of Somatic Cells into Pluripotent ES-like CellsR37HD045022 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF · 2009 to 2017
$7.5MTranscriptional condensates, epigenetic editing and Rett SyndromeR01MH104610 · NIMH · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, YOUNG, RICHARD · 2014 to 2023
$7.4MMitochondrial Complex I as a Target for Neuroprotection in ADRF1AG055549 · NIA · MAYO CLINIC ROCHESTER · PI TRUSHINA, EUGENIA · 2017 to 2025
$7.0MAn iPSC based platform for functionally assessing genetic and environmental riskR01NS088538 · NINDS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, MYERS, RICHARD H · 2014 to 2018
$5.0MNuclear Cloning and the Reprogramming of the GenomeR01HD045022 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF · 2003 to 2008
$4.7MSmall Molecule Mitochondria-Targeted Therapeutics for AD (Supplement)UH3NS113776 · NINDS · MAYO CLINIC ROCHESTER · PI TRUSHINA, EUGENIA · 2022 to 2022
$1.1MSmall molecule mitochondria-targeted therapeutics for ADUG3NS113776 · NINDS · MAYO CLINIC ROCHESTER · PI TRUSHINA, EUGENIA · 2021 to 2021
$785kMedical Research Council MR/P020941/1NIA NIH HHS RF1 AG055549NICHD NIH HHS R01 HD045022NICHD NIH HHS R37 HD045022NIMH NIH HHS R01 MH104610NINDS NIH HHS R01 NS088538NINDS NIH HHS UG3 NS113776NINDS NIH HHS UH3 NS113776Wellcome Trust 204715/Z/16/ZWellcome Trust 212241/Z/18/Z
Abstract
Autophagy is an essential catabolic process that promotes the clearance of surplus or damaged intracellular components. Loss of autophagy in age-related human pathologies contributes to tissue degeneration through a poorly understood mechanism. Here, we identify an evolutionarily conserved role of autophagy from yeast to humans in the preservation of nicotinamide adenine dinucleotide (NAD) levels, which are critical for cell survival. In respiring mouse fibroblasts with autophagy deficiency, loss of mitochondrial quality control was found to trigger hyperactivation of stress responses mediated by NADases of PARP and Sirtuin families. Uncontrolled depletion of the NAD(H) pool by these enzymes ultimately contributed to mitochondrial membrane depolarization and cell death. Pharmacological and genetic interventions targeting several key elements of this cascade improved the survival of autophagy-deficient yeast, mouse fibroblasts, and human neurons. Our study provides a mechanistic link between autophagy and NAD metabolism and identifies targets for interventions in human diseases associated with autophagic, lysosomal, and mitochondrial dysfunction.
Indexed as
NADSaccharomyces cerevisiaeAnimalsAutophagyCell DeathCell SurvivalHumansMiceNADageingautophagyDNA damagemetabolismmitochondriamitophagyNADPARPSirtuins
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