ArticleProceedings of the National Academy of Sciences of the United States of America2022
Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- A novel anaerobic cholinergic signaling compound, β-alanine betaine, and nAChRs in Ascaris.PLoS neglected tropical diseases · 2026Article
- TAXISCAN, Optimizing throughput and behavioral depth in standardbioRxiv : the preprint server for biology · 2026Article
- β-alanine betaine and nAChRs inbioRxiv : the preprint server for biology · 2026Article
- Glycine betaine alleviates salt stress in tomato by enhancing the chlorophyll synthesis pathway, photosynthesis, and regulating mBMC plant biology · 2026Article
- Identity and functions of monoaminergic neurons in the predatory nematodebioRxiv : the preprint server for biology · 2025Article
- Enhancing Reproducibility in Chemotaxis Assays for Caenorhabditis elegans.Current protocols · 2025Article
- A neurotransmitter atlas ofeLife · 2024Article
- Structural insights into the molecular effects of the anthelmintics monepantel and betaine on the Caenorhabditis elegans acetylcholine receptor ACR-23.The EMBO journal · 2024Article
- Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1).Cellular and molecular life sciences : CMLS · 2024Article
- A neurotransmitter atlas ofbioRxiv : the preprint server for biology · 2024Article
- Vitamin BNature cell biology · 2024Article
- The diverse family of Cys-loop receptors inBiophysical reviews · 2023Review
- Making the case for prophylactic use of betaine to promote brain health in young (15-24 year old) athletes at risk for concussion.Frontiers in neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Trimethylglycine, or betaine, is an amino acid derivative found in diverse organisms, from bacteria to plants and animals, with well-established functions as a methyl donor and osmolyte in all cells. In addition, betaine is found in the nervous system, though its function there is not well understood. Here, we show that betaine is synthesized in the nervous system of the nematode worm,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.