ArticleJournal of the American Chemical Society2022
Functional Water Networks in Fully Hydrated Photosystem II.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of high light and elevated temperature on the structure of photosystem II isolated from Arabidopsis thaliana.Photosynthesis research · 2026Article
- Entangled hydrophobic and hydrophilic networks in carbon monoxide dehydrogenase.Chemical science · 2026Article
- Asymmetric Connectivity Between Redox-Active Tyrosines and Reaction-Center Chlorophylls in Photosystem II.Plants (Basel, Switzerland) · 2026Article
- Water-modulated conformational heterogeneity underlies multiple timescales of primary charge separation in photosystem II.Nature communications · 2026Article
- The contribution of thePhotosynthesis research · 2026Article
- The structure of intact and active Photosystem II from Arabidopsis thaliana at 2.44 Å resolution.The New phytologist · 2026Article
- Water engineering via surfactant coacervates enables efficient and robust solar hydrogen evolution.Nature communications · 2026Article
- Met246 and Asn250 in the D2 protein are essential for the operation of the quinone-Fe-acceptor complex of Photosystem II.Plant & cell physiology · 2025Article
- Structure of the D1-Val185Asn mutated photosystem II complex with slow O-O bond formation reveals changes in the Cl1 water channel.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Three rate-determining protein roles in photosynthetic ONature communications · 2025Article
- Ammonia Binding to the Oxygen-Evolving Complex Probed by High-Energy Resolution Fluorescence Detected X-Ray Absorption Spectroscopy.The journal of physical chemistry. B · 2025Article
- Mechanism of proton release during water oxidation in Photosystem II.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Theoretical elucidation of the structure, bonding, and reactivity of the CaMnPhotosynthesis research · 2024Review
- Conformational control over proton-coupled electron transfer in metalloenzymes.Nature reviews. Chemistry · 2024Review
- Closing Kok's cycle of nature's water oxidation catalysis.Nature communications · 2024Article
- The Effect of Removal of External Proteins PsbO, PsbP and PsbQ on Flash-Induced Molecular Oxygen Evolution and Its Biphasicity in Tobacco PSII.Current issues in molecular biology · 2024Article
- Mutation-induced shift of the photosystem II active site reveals insight into conserved water channels.The Journal of biological chemistry · 2024Article
- Excitation landscape of the CP43 photosynthetic antenna complex from multiscale simulations.Chemical science · 2024Article
- Comprehensive Evaluation of Models for Ammonia Binding to the Oxygen Evolving Complex of Photosystem II.The journal of physical chemistry. B · 2024Article
- Reaction Center Excitation in Photosystem II: From Multiscale Modeling to Functional Principles.Accounts of chemical research · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water channels and networks within photosystem II (PSII) of oxygenic photosynthesis are critical for enzyme structure and function. They control substrate delivery to the oxygen-evolving center and mediate proton transfer at both the oxidative and reductive endpoints. Current views on PSII hydration are derived from protein crystallography, but structural information may be compromised by sample dehydration and technical limitations. Here, we simulate the physiological hydration structure of a cyanobacterial PSII model following a thorough hydration procedure and large-scale unconstrained all-atom molecular dynamics enabled by massively parallel simulations. We show that crystallographic models of PSII are moderately to severely dehydrated and that this problem is particularly acute for models derived from X-ray free electron laser (XFEL) serial femtosecond crystallography. We present a fully hydrated representation of cyanobacterial PSII and map all water channels, both static and dynamic, associated with the electron donor and acceptor sides. Among them, we describe a series of transient channels and the attendant conformational gating role of protein components. On the acceptor side, we characterize a channel system that is absent from existing crystallographic models but is likely functionally important for the reduction of the terminal electron acceptor plastoquinone Q
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