ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2023
Geographic Patterns in U.S. Lung Cancer Mortality and Cigarette Smoking.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mapping the mortality niche of chronic lower respiratory diseases complicated by respiratory failure: a multiscale spatial analysis of environmental and social drivers.Frontiers in public health · 2026Article
- Identifying early-life, environmental, and social stressors as key predictors of U.S. respiratory failure mortality: a machine learning study.Frontiers in public health · 2026Article
- Bridging Mammography and Lung Cancer Screening: Eligibility, Uptake and Potential Impact.Cancer medicine · 2026Article
- Assessing spatial disparities: a Bayesian linear regression approach.Biostatistics (Oxford, England) · 2025Article
- Comparative Evaluation of Explainable Machine Learning Versus Linear Regression for Predicting County-Level Lung Cancer Mortality Rate in the United States.JCO clinical cancer informatics · 2025Article
- Identifying communities where older adults with major cancer diagnoses are contending with high levels of natural hazards.Cancer causes & control : CCC · 2025Article
- Where Should the Cancer Control Interventions Target: A Geospatial Hotspot Analysis for Major Cancer Mortality 2018 to 2022 in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Sex-specific radiation-associated lung cancer mortality risks as impacted by smoking among US radiological technologists.Journal of the National Cancer Institute · 2025Article
- Geographic patterns in wildland fire exposures and county-level lung cancer mortality in the United States.International journal of health geographics · 2025Article
- Investigating sex, race, and geographic disparities in bronchus and lung cancer mortality in the United States: a comprehensive longitudinal study (1999-2020) utilizing CDC WONDER data.Annals of medicine and surgery (2012) · 2024Review
- Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis.EXCLI journal · 2024Review
- Cancer Epidemiology in the Northeastern United States (2013-2017).Cancer research communications · 2023Article
- Factors Associated with Delaying and Forgoing Care Due to Cost among Long-term, Appalachian Cancer Survivors in Rural North Carolina.Cancer survivorship research & care · 2023Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundDespite the success of smoking cessation campaigns, lung cancer remains the leading cause of cancer death in the U.S. Variations in smoking behavior and lung cancer mortality are evident by sex and region.
methodsApplying geospatial methods to lung cancer mortality data from the National Vital Statistics System and county-level estimates of smoking prevalences from the NCI's Small Area Estimates of Cancer-Related Measures, we evaluated patterns in lung cancer mortality rates (2005-2018) in relation to patterns in ever cigarette smoking prevalences (1997-2003).
resultsOverall, ever smoking spatial patterns were generally associated with lung cancer mortality rates, which were elevated in the Appalachian region and lower in the West for both sexes. However, we also observed geographic variation in mortality rates that is not explained by smoking. Using Lee's L statistic for assessing bivariate spatial association, we identified counties where the ever smoking prevalence was low and lung cancer rates were high. We observed a significant cluster of counties (n = 25; P values ranging from 0.001 to 0.04) with low ever smoking prevalence and high mortality rates among females around the Mississippi River region south of St. Louis, Missouri and a similar and smaller cluster among males in Western Mississippi (n = 12; P values ranging from 0.002 to 0.03) that has not been previously described.
conclusionsOur analyses identified U.S. counties where factors other than smoking may be driving lung cancer mortality. IMPACT: These novel findings highlight areas where investigation of environmental and other risk factors for lung cancer is needed.
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