Evidence map›Paper›PMID 36413274›Full record

ArticleClinical and experimental medicine2023

CYP51-mediated cholesterol biosynthesis is required for the proliferation of CD4

Junhao Yin, Jiayao Fu, Yanxiong Shao, Jiabao Xu, Hui Li, Changyu Chen, Yijie Zhao, Zhanglong Zheng, Chuangqi Yu, Lingyan Zheng and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical and experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Lipid Metabolism: An Emerging Player in Sjögren's Syndrome.Clinical reviews in allergy & immunology · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Junhao Yin *Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Jiayao Fu *Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Yanxiong ShaoDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Jiabao XuDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Hui LiDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Changyu ChenDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Yijie ZhaoDepartment of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, 1258 Fuxin Zhong Road, Shanghai, China.
Zhanglong ZhengDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Chuangqi YuDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Lingyan ZhengDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China. zhenglingyan1973@163.com.
Baoli WangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China. wangbaoli7323581@126.com.
Shanghai Ninth People's Hospital · CNShanghai Jiao Tong University · CNFudan University · CNTongji University · CN

Funding

Biological sample bank project of Ninth People's Hospital Affiliated to Shanghai Jiao Tong university School of Medicine YBKB202107Fundamental research program funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong university School of Medicine JYZZ132National Natural Science Foundation of China 82001064The 15th undergraduate training program for innovation of Shanghai Jiaotong University School of medicine 1521Y591The Cross project of Shanghai Ninth people's hospital affiliated to Shanghai Jiaotong University of Medicine and Shanghai Science and Technology University JYJC202126Yangfan program of Shanghai Science and Technology Committee 22YF1422100
6 · The paper itself

Abstract

CYtochrome P450, family 51 (CYP51) is an important enzyme for de novo cholesterol synthesis in mammalian cells. In the present study, we found that the expression of CYP51 positively correlated with CD4

Indexed as

KetoconazoleSjogren's SyndromeAnimalsCD4-Positive T-LymphocytesCell ProliferationCholesterolCytochrome P-450 Enzyme SystemHumansMammalsMiceMice, Inbred NODSterol 14-DemethylaseT-LymphocytesCholesterolCYP51A1 protein, humanCytochrome P-450 Enzyme SystemKetoconazoleSterol 14-DemethylaseCD4+ T cellCYP51Integrated stress responseKetoconazoleSjogren’s syndrome

Identifiers

PMID36413274
OpenAlexW4309663442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.