ArticleSchizophrenia bulletin2023
The Behavioral Mapping of Psychomotor Slowing in Psychosis Demonstrates Heterogeneity Among Patients Suggesting Distinct Pathobiology.
Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Clinical and neurobiological correlates of tardive dyskinesia in schizophrenia spectrum disorders and mood disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Instrumented gait characteristics and short-term changes after CAREN training in ischemic stroke: a pilot study.Frontiers in psychiatry · 2026Article
- Functional organization of the primary motor cortex in psychosis and the potential role of intereffector regions in psychomotor slowing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Grip Strength as a Marker of Resting-State Network Integrity and Well-Being in Early Psychosis.The American journal of psychiatry · 2025Article
- Testing a Motor Score Based on PANSS Ratings: A Proxy for Comprehensive Motor Assessment.Schizophrenia bulletin · 2025Article
- Capturing Motor Signs in Psychosis: How the New Technologies Can Improve Assessment and Treatment?Schizophrenia bulletin · 2025Article
- Psychosis and diving.Diving and hyperbaric medicine · 2025Review
- Reduced finger tapping speed in patients with schizophrenia and psychomotor slowing: an exploratory fMRI study.Frontiers in psychiatry · 2025Article
- Psychomotor slowing in schizophrenia is associated with aberrant postural control.Schizophrenia (Heidelberg, Germany) · 2024Article
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
- The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity.Brain : a journal of neurology · 2024Article
- The Moderating Role of Anxiety and Depressive Symptoms in Protective Effects of Health Behaviors among Clients Using Mental Health Services.Journal of clinical medicine · 2024Article
- Aberrant brain dynamics in individuals with clinical high risk of psychosis.Schizophrenia bulletin open · 2024Article
- Resting-state perfusion in motor and fronto-limbic areas is linked to diminished expression of emotion and speech in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Psychomotor slowing alters gait velocity, cadence, and stride length and indicates negative symptom severity in psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPsychomotor slowing (PS) occurs in up to half of schizophrenia patients and is linked to poorer outcomes. As standard treatment fails to improve PS, novel approaches are needed. Here, we applied the RDoC framework using 3 units of analysis, ie, behavior, self-report, and physiology to test, whether patients with PS are different from patients without PS and controls.
methodsMotor behavior was compared between 71 schizophrenia patients with PS, 25 without PS, and 42 healthy controls (HC) using 5 different measures: (1) for behavior, an expert rating scale: Motor score of the Salpêtrière Retardation Rating Scale, (2) for self-report, the International Physical Activity Questionnaire; and for physiology, (3) Actigraphy, which accounts for gross motor behavior, (4) Gait velocity, and (5) coin rotation task to assess manual dexterity.
resultsThe ANCOVAs comparing the 3 groups revealed differences between patients with PS and HC in expert ratings, self-report, and instrumental measures (all P ≤ .001). Patients with PS also scored higher in expert ratings and had lower instrumental activity levels compared to patients without PS (all P ≤ .045). Instrumental activity levels correlated with an expert rating of PS (rho = -0.51, P-fdr corrected <.001) and classified similarly at 72% accuracy.
conclusionsPS is characterized by slower gait, lower activity levels, and slower finger movements compared to HC. However, only actigraphy and observer ratings enable to clearly disentangle PS from non-PS patients. Actigraphy may become the standard assessment of PS in neuroimaging studies and clinical trials.
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