Evidence map›Paper›PMID 36412975›Full record

Observational studyUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2023

Antenatal corticosteroids and perinatal outcome in late fetal growth restriction: analysis of prospective cohort.

A Familiari, R Napolitano, G H A Visser, C Lees, H Wolf, F Prefumo, TRUFFLE-2 feasibility study investigators

Open access · hybridAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Understanding a Potential Role for the NLRP3 Inflammasome in Placenta-Mediated Pregnancy Complications.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Review
  5. Article
  6. Administration of Antenatal Corticosteroids: Optimal Timing.Geburtshilfe und Frauenheilkunde · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

A FamiliariDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID 0000-0002-6353-9383
R NapolitanoElizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.ORCID 0000-0002-8512-2597
G H A VisserDepartment of Obstetrics, University Medical Center, Utrecht, The Netherlands.ORCID 0000-0001-6708-6396
C LeesCentre for Fetal Care, Department of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, Imperial College London, London, UK.ORCID 0000-0002-2104-5561
H WolfDepartment of Obstetrics and Gynecology, Amsterdam University Medical Center (Location AMC), University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-3924-2149
F PrefumoObstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0001-7793-714X
TRUFFLE-2 feasibility study investigators
Agostino Gemelli University Polyclinic · ITAmsterdam University Medical Centers · NLIstituto Giannina Gaslini · ITQueen Charlotte's and Chelsea Hospital · GBUniversity College Hospital · GBUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the role of antenatal administration of corticosteroids for fetal lung maturation on the short-term perinatal outcome of pregnancy complicated by late fetal growth restriction (FGR).

methodsThis cohort study was a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. The study included women with a singleton pregnancy from 32 + 0 to 36 + 6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) and/or fetal abdominal circumference < 10

resultsA total of 86 pregnancies that received ACS were matched to 86 controls. The two groups were similar with respect to gestational age (33.1 vs 33.3 weeks), EFW (1673 vs 1634 g) and UCR (0.68 vs 0.62) at inclusion, and gestational age at delivery (35.5 vs 35.9 weeks) and birth weight (1925 vs 1948 g). No significant differences were observed between the exposed and non-exposed groups in the incidence of composite adverse outcome (28% vs 24%; P = 0.73) or any of its elements.

conclusionThe present data do not show a beneficial effect of steroids on short-term outcome of fetuses with late FGR. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Indexed as

Fetal Growth RetardationInfant, Small for Gestational AgeAdrenal Cortex HormonesBirth WeightCohort StudiesFemaleFetal WeightGestational AgeHumansInfantInfant, NewbornParturitionPregnancyProspective StudiesUltrasonography, PrenatalAdrenal Cortex Hormonesantenatal corticosteroidsfetal growth restrictionfetal lung maturationlate preterm

Identifiers

PMID36412975
PMCPMC10108243
OpenAlexW4309663445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.