Evidence map›Paper›PMID 36412916›Full record

Trial reportIntegrative cancer therapies

Yoga Therapy During Chemotherapy for Early-Stage and Locally Advanced Breast Cancer.

Samantha K Greaney, Neha Amin, Bethany C Prudner, Maggie Compernolle, Linda J Sandell, Susan C Tebb, Katherine N Weilbaecher, Peri Abeln, Jingqin Luo, Yu Tao and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03262831 (The Role of Mindful Movement in Women Receiving Adjuvant or Neoadjuvant Therapy for Breast Cancer), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03262831 nacompletednot on this map

The Role of Mindful Movement in Women Receiving Adjuvant or Neoadjuvant Therapy for Breast Cancer

TypeinterventionalSponsorWashington University School of MedicineRan2018 to 2019Enrolled30ConditionsBreast Cancer, Cancer of BreastArmsYoga, Blood draw, FACT-G questionnaire, Weight measurement, Recent Physical Activity Questionnaire
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Samantha K GreaneyWashington University School of Medicine, Saint Louis, MO, USA.
Neha AminWashington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-5128-9065
Bethany C PrudnerWashington University School of Medicine, Saint Louis, MO, USA.
Maggie CompernolleBarnes-Jewish Hospital, Saint Louis, MO, USA.
Linda J SandellWashington University School of Medicine, Saint Louis, MO, USA.
Susan C TebbSaint Louis University, Saint Louis, MO, USA.
Katherine N WeilbaecherWashington University School of Medicine, Saint Louis, MO, USA.
Peri AbelnWashington University School of Medicine, Saint Louis, MO, USA.
Jingqin LuoWashington University School of Medicine, Saint Louis, MO, USA.
Yu TaoWashington University School of Medicine, Saint Louis, MO, USA.
Angela C HirbeWashington University School of Medicine, Saint Louis, MO, USA.
Lindsay L PetersonWashington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-5012-7347
Washington University in St. Louis · USBarnes-Jewish Hospital · USSaint Louis University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

backgroundChemotherapy is associated with decreased quality of life (QOL), fatigue, depression, and weight gain in patients with breast cancer. Weight gain is associated with poorer prognosis. Yoga improves QOL, fatigue, and mood in women with breast cancer but its effect on treatment-related weight gain has not been studied. The aim of this trial was to determine the feasibility of personalized yoga therapy in women receiving treatment for early-stage or locally advanced breast cancer and assess its impact on weight gain.

methodsThirty women were randomized 1:1 to receive yoga therapy by a certified yoga therapist during treatment or a control group. Participants in the yoga arm were asked to complete three 30 minute yoga sessions weekly (which included movement, breath work, mindfulness, and relaxation) throughout adjuvant or neoadjuvant chemotherapy (N = 29) or endocrine (N = 1); the control arm received breast cancer treatment without yoga. For comparability between participants randomized to yoga therapy, the single patient treated with endocrine therapy was excluded from the analysis. Primary outcomes were feasibility and weight change. Additional outcomes were mood, fatigue, QOL, serum tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) as immune mediator biomarkers.

resultsMean age was 51.6 years, 75.9% were white and 24.1% were people of color, reflecting the cancer center population. 80% had stage II-III disease. Enrollment was completed in 9 months. Compliance was lower than predicted; however, participants participated in on average 1.7 yoga sessions/week for a mean 15.6 weeks duration. There were no adverse events. Control arm participants gained on average 2.63% body weight during treatment while yoga participants lost 0.14% body weight (weight change = -0.36 in yoga arm vs. 2.89 in standard of care arm, Wilcoxon rank sum test

conclusionThis feasibility study suggests that personalized yoga therapy is beneficial for QOL and weight maintenance among women undergoing chemotherapy for early-stage or locally advanced breast cancer. Weight maintenance associated with yoga therapy may be of clinical significance in this population given the poorer prognosis associated with weight gain in breast cancer survivors.

trial registrationNIH Clinicaltrials.gov #NCT03262831; August 25, 2017. https://clinicaltrials.gov/ct2/show/NCT03262831.

Indexed as

Breast NeoplasmsYogaBody WeightFatigueFemaleHumansMiddle AgedQuality of LifeTumor Necrosis Factor-alphaWeight GainTumor Necrosis Factor-alphabreast cancerchemotherapymindfulnessquality of lifeweightyoga

Identifiers

PMID36412916
PMCPMC9706042
OpenAlexW4309658575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.