ReviewJournal of functional biomaterials2022
Regulating Macrophages through Immunomodulatory Biomaterials Is a Promising Strategy for Promoting Tendon-Bone Healing.
Review in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Machine learning-guided discovery of a bioactive hydrogel for spatiotemporally orchestrated tendon-to-bone healing.Bioactive materials · 2026Article
- Didymin may Enhance Tendon-Bone Healing Partly by Promoting PPAR-Mediated Fatty Acid Oxidation and Macrophage M2 Polarization.Immunity, inflammation and disease · 2026Article
- Multi-Omics Profiling Reveals Immunomodulatory and Pro-Regenerative Effects of a Graphene Oxide-Collagen Scaffold in Massive Rotator Cuff Tears.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Bibliometric analysis of enthesis research: a comprehensive review from 1999 to 2024.International orthopaedics · 2026Review
- Recent advances in immunoregulatory biomaterials for tendon healing: From immune remodeling to functional regeneration.Materials today. Bio · 2026Review
- Highly bio-adapted hydrogels for tendon-bone interface regeneration: Natural healing inspiration, design strategies, and biomedical potential.Bioactive materials · 2026Review
- Exosomes derived from BMSCs regulate macrophage M1/M2 polarization and promoting tendon-bone healing through circRNA1052.Stem cell research & therapy · 2026Article
- Macrophage polarisation under immune regulation as a therapeutic target for tendon-bone healing: multifactorial regulation and mechanistic insights.Frontiers in immunology · 2026Review
- Advanced engineering strategies for biomaterial scaffolds application in tendon-bone interface regeneration.Burns & trauma · 2026Review
- bFGF-genetically modified bone marrow-derived mesenchymal stem cells promote tendon-to-bone interface healing by promoting chondrogenesis and regulating macrophage polarization.Frontiers in bioengineering and biotechnology · 2026Article
- Multidimensional biomimetic strategy integrating structural, functional and biological cues for enhanced tendon-to-bone interface regeneration.Materials today. Bio · 2025Article
- Total Flavonoids ofBiology · 2025Article
- SHED-derived exosome-mimetics promotes rotator cuff tendon-bone healing via macrophage immunomodulation through NF-κB suppression and autophagy activation.Materials today. Bio · 2025Article
- Screening of hub genes and immunocytes related to tendon injury based on bioinformatics and machine learning models.Scientific reports · 2025Article
- Healing of tendon-related diseases: insights from macrophage regulation.Military Medical Research · 2025Review
- Microsphere Strategy to Generate Conformal Bone Organoid Units with Osteoimmunomodulation and Sustainable Oxygen Supply for Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Rationale and methodology for injection therapy to treat rotator cuff disease: a scoping review.Clinics in shoulder and elbow · 2025Article
- The P2X7R/NLRP3 inflammasome axis suppresses enthesis regeneration through inflammatory and metabolic macrophage-stem cell cross-talk.Science advances · 2025Article
- Injectable Piezoelectric Hydrogel Promotes Tendon-Bone Healing via Reshaping the Electrophysiological Microenvironment and M2 Macrophage Polarization.ACS applied materials & interfaces · 2025Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
The tendon-to-bone interface is a special structure connecting the tendon and bone and is crucial for mechanical load transfer between dissimilar tissues. After an injury, fibrous scar tissues replace the native tendon-to-bone interface, creating a weak spot that needs to endure extra loading, significantly decreasing the mechanical properties of the motor system. Macrophages play a critical role in tendon-bone healing and can be divided into various phenotypes, according to their inducing stimuli and function. During the early stages of tendon-bone healing, M1 macrophages are predominant, while during the later stages, M2 macrophages replace the M1 macrophages. The two macrophage phenotypes play a significant, yet distinct, role in tendon-bone healing. Growing evidence shows that regulating the macrophage phenotypes is able to promote tendon-bone healing. This review aims to summarize the impact of different macrophages on tendon-bone healing and the current immunomodulatory biomaterials for regulating macrophages, which are used to promote tendon-bone healing. Although macrophages are a promising target for tendon-bone healing, the challenges and limitations of macrophages in tendon-bone healing research are discussed, along with directions for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.