ArticleAntibodies (Basel, Switzerland)2022
Cross-Reactive Antibodies in Tick-Borne Encephalitis: Case Report and Literature Review.
Article in Antibodies (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Anti-Dengue IgG Seroprevalence and Exposure-Related Risk in Italian Military Personnel Deployed on Overseas Missions: A Cross-Sectional Study.Tropical medicine and infectious disease · 2026Article
- West Nile Virus in Horses as a Sentinel Host in One Health Surveillance: Epidemiological Insights and Future Perspectives.Microorganisms · 2026Review
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- Clinical Characteristics, Laboratory Parameters, and Molecular Epidemiology of Neuroinvasive Flavivirus Infections in a Hotspot Region of Eastern Croatia.Pathogens (Basel, Switzerland) · 2025Article
- Study of the influence of population immunity to tick-borne encephalitis virus on the characteristics of the epidemic process in Russia.Frontiers in immunology · 2025Article
- [Laboratory Diagnosis of Omsk Hemorrhagic Fever Virus and Kyasanur Forest Disease Virus].Jugan geon-gang gwa jilbyeong · 2024Review
- The Re-Emergence of Neuroinvasive Flaviviruses in Croatia During the 2022 Transmission Season.Microorganisms · 2024Article
- Tick-borne zoonotic flaviviruses andOne health (Amsterdam, Netherlands) · 2024Review
- Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections.Microorganisms · 2024Article
- An Overview of Tick-Borne Encephalitis Epidemiology in Endemic Regions of Continental Croatia, 2017-2023.Microorganisms · 2024Article
- Powassan Virus Encephalitis: A Tertiary Center Experience.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Tick-Borne Encephalitis in a 6-Year-Old Patient: A Case Report.The Neurohospitalist · 2024Article
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- A comprehensive neurological perspective on tick-borne flaviviruses, with emphasis on Powassan virus.Therapeutic advances in infectious diseaseReview
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Flaviviruses are a heterogeneous group of viruses that may induce broad antigenic cross-reactivity. We present a patient who was admitted to the infectious disease department with symptoms suggestive of aseptic meningitis. During the clinical workup, the patient reported a tick bite two weeks before the disease onset. High titers of IgM and IgG antibodies to tick-borne encephalitis virus (TBEV) were found in both serum and cerebrospinal fluid (CSF) samples, indicating acute TBEV infection. West Nile virus (WNV) and Usutu virus (USUV) IgM and/or IgG antibodies were also detected, and a virus neutralization test (VNT) was performed. A high titer of TBEV neutralizing (NT) antibodies (640) was detected, which confirmed acute TBE. However, NT antibodies to WNV and USUV were also detected (titer 80 for both viruses). After TBEV and WNV IgG avidity evaluation, previous flavivirus infection was highly suspected (avidity index 82% and 89%, respectively). Blood, CSF, and urine samples were negative for respective viruses' RNA. The presented case highlights the challenges in flavivirus serodiagnosis. In the published literature, different degrees of cross-reactivity or cross-neutralization between TBEV and dengue, louping ill, Omsk hemorrhagic fever, Langat, and Powassan virus were also observed. Therefore, the serology results should be interpreted with caution, including the possibility of cross-reactivity. In areas where several flaviviruses co-circulate VNT is recommended for disease confirmation.
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