ArticleeLife2022
The genetic risk of gestational diabetes in South Asian women.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Precision medicine in low-income settings and small island developing states.Nature reviews. Endocrinology · 2026Review
- Drivers of Atherosclerotic Cardiovascular Disease in South Asians: Current Insights and Future Directions.JACC. Asia · 2026Review
- Ethnic differences in pregnancies complicated by gestational diabetes mellitus: a multiethnic cohort study.Endocrine · 2026Observational
- Redefining the challenges of gestational diabetes mellitus in ethnically diverse populations.Endocrine · 2026Article
- Polygenic Risk Score Associated with Gestational Diabetes Mellitus in an AmericanIndian Population.Journal of personalized medicine · 2025Article
- Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and Health.AJOG global reports · 2025Article
- Trends in induction of labour and associated co-morbidities and demographics in Queensland, Australia from 2001 to 2020: a population-based study.BMC pregnancy and childbirth · 2025Article
- High-Risk Consult Multidisciplinary Team in a Tertiary Maternity Unit: Changing Prevalence of Cases.Journal of multidisciplinary healthcare · 2025Article
- Characterizing sociodemographic disparities and predictors of Gestational Diabetes Mellitus among Asian and Native Hawaiian or other Pacific Islander pregnant people: an analysis of PRAMS data, 2016-2022.BMC pregnancy and childbirth · 2024Article
- Association Between the EAT-Lancet Reference Diet and Gestational Diabetes Mellitus: A Mini-Review.Nutrients · 2024Review
- Article
- Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts.Clinical epigenetics · 2024Article
- Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population.International journal of molecular sciences · 2024Article
- The association of red and processed meat with gestational diabetes mellitus: Results from 2 Canadian birth cohort studies.PloS one · 2024Article
- Prevention of Cardiovascular Disease in Women With Pregnancy-Related Risk Factors: A Prospective Women's Heart Clinic Study.Journal of the American Heart Association · 2023Article
- Article
- Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
South Asian women are at increased risk of developing gestational diabetes mellitus (GDM). Few studies have investigated the genetic contributions to GDM risk. We investigated the association of a type 2 diabetes (T2D) polygenic risk score (PRS), on its own, and with GDM risk factors, on GDM-related traits using data from two birth cohorts in which South Asian women were enrolled during pregnancy. 837 and 4372 pregnant South Asian women from the SouTh Asian BiRth CohorT (START) and Born in Bradford (BiB) cohort studies underwent a 75-g glucose tolerance test. PRSs were derived using genome-wide association study results from an independent multi-ethnic study (~18% South Asians). Associations with fasting plasma glucose (FPG); 2 hr post-load glucose (2hG); area under the curve glucose; and GDM were tested using linear and logistic regressions. The population attributable fraction (PAF) of the PRS was calculated. Every 1 SD increase in the PRS was associated with a 0.085 mmol/L increase in FPG ([95% confidence interval, CI=0.07-0.10], p=2.85×10
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