Evidence map›Paper›PMID 36412257›Full record

ArticleFly2022

A screen of small molecule and genetic modulators of life span in female

Gary N Landis, Sebastian Ko, Oscar Peng, Brett Bognar, Michael Khmelkov, Hans S Bell, John Tower

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fly, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Progressive behavioral and cognitive decline inbioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gary N LandisMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Sebastian KoMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Oscar PengMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Brett BognarMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Michael KhmelkovMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Hans S BellMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
John TowerMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
University of Southern California · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Sex-Specific Aging MechanismsR01AG057741 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOWER, JOHN GERARD · 2018 to 2021
$1.5M
NIA NIH HHS R01 AG057741NIH HHS P40 OD018537
6 · The paper itself

Abstract

Mifepristone increases life span in female

Indexed as

Drosophila ProteinsLongevityAnimalsDNA-Binding ProteinsDrosophilaDrosophila melanogasterEcdysoneEpoxy CompoundsFemaleHypertrophyMammalsMifepristonePioglitazoneTemperatureTranscription FactorsDNA-Binding ProteinsDrosophila ProteinsEcdysoneEip75B protein, DrosophilaEpoxy CompoundsetomoxirMifepristonePioglitazoneTranscription FactorsAgeingclimate changeecdysoneGAL4/GAL80tsmifepristonepioglitazonesex differencessteroid

Identifiers

PMID36412257
PMCPMC9683069
OpenAlexW4309556538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.