Evidence map›Paper›PMID 36412169›Full record

ArticleThe Journal of physiology2023

Distinct mechanisms of CB1 and GABA

Giacomo Sitzia, Karina Possa Abrahao, Daniel Liput, Gian Marco Calandra, David M Lovinger

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Spontaneous Activity of the Local GABAergic Synaptic Network Causes Irregular Neuronal Firing in the External Globus Pallidus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Giacomo SitziaLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, Maryland, USA.ORCID 0000-0003-2244-4393
Karina Possa AbrahaoDepartamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil.
Daniel LiputLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, Maryland, USA.
Gian Marco CalandraInstitute for Stroke and Dementia Research, Ludwig-Maximilians-Universität, Munich, Germany.
David M LovingerLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, Maryland, USA.
National Institutes of Health · USLudwig-Maximilians-Universität München · DEUniversidade Federal de São Paulo · BR

Funding

Corticostriatal mechanisms of action learning and habit formationZIAAA000416 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2009 to 2025
$25.2M
Intramural NIH HHS ZIA AA000416Intramural NIH HHS ZIAAA000416NIAAA NIH HHS
6 · The paper itself

Abstract

Presynaptic modulation is a fundamental process regulating synaptic transmission. Striatal indirect pathway projections originate from A2A-expressing spiny projection neurons (iSPNs), targeting the globus pallidus external segment (GPe) and control the firing of the tonically active GPe neurons via GABA release. It is unclear if and how the presynaptic G-protein-coupled receptors (GPCRs), GABA

Indexed as

gamma-Aminobutyric AcidGlobus PallidusAnimalsCalciumCorpus StriatumMiceReceptors, GABA-BCalciumgamma-Aminobutyric AcidReceptors, GABA-Bbasal gangliacalcium imagingneurotransmitter releaseoptogeneticspresynaptic

Identifiers

PMID36412169
PMCPMC10107704
OpenAlexW4309656106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.