Evidence map›Paper›PMID 36412091›Full record

ArticleeLife2022

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape.

James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Role of Senescent Astrocytes in Health and Disease.International journal of molecular sciences · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

James BootBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.ORCID 0000-0002-5629-5026
Gabriel RosserBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.
Dailya KanchevaLaboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
Claire VinelBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.
Yau Mun LimDivision of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, and Department of Neurodegenerative Disease, Queen Square, Institute of Neurology, University College London, London, United Kingdom.ORCID 0000-0002-8774-9537
Nicola PomellaBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.
Xinyu ZhangBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.
Loredana GuglielmiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.
Denise SheerBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.
Michael BarnesCentre for Translational Bioinformatics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Sebastian BrandnerDivision of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, and Department of Neurodegenerative Disease, Queen Square, Institute of Neurology, University College London, London, United Kingdom.
Sven NelanderDepartment of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-1758-1262
Kiavash MovahediLaboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-0826-4399
Silvia MarinoBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom.ORCID 0000-0002-9612-2883
Queen Mary University of London · GBUniversity College London Hospitals NHS Foundation Trust · GBVrije Universiteit Brussel · BEUppsala University · SE

Funding

Cancer Research UK 29199Cancer Research UK C23985/A29199
6 · The paper itself

Abstract

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identification of enriched predicted binding sites of transcription factors known to cause demethylation and to be involved in astrocytic/glial lineage specification, point to a shared ontogeny between these glioblastomas and astroglial progenitors. At functional level, increased invasiveness, at least in part mediated by SRPX2, and macrophage infiltration characterise this subset of glioblastoma.

Indexed as

Brain NeoplasmsGlioblastomaAdultAstrocytesDNA MethylationEpigenomicsHumansastrocytescancer biologyDNA methylationglioblastomahumanmouse

Identifiers

PMID36412091
PMCPMC9681209
OpenAlexW4309662247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.