Evidence map›Paper›PMID 36411911›Full record

ArticleHeliyon2022

A case of successful treatment with antiretroviral therapy for HIV in a patient with marked liver dysfunction.

Hirofumi Fukuda, Yosuke Kondo, Sohji Nishina, Hironobu Ohumi, Yasuyuki Tomiyama, Akihiko Kanki, Hidemitsu Sotozono, Seiya Hashimoto, Harunoshin Yasui, Risa Shimizu and 3 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Hirofumi FukudaDepartment of Hematology, Kawasaki Medical School, Kurashiki, Japan.
Yosuke KondoDepartment of Hematology, Kawasaki Medical School, Kurashiki, Japan.
Sohji NishinaDepartment of Hepatology and Pancreatology, Kawasaki Medical School, Kurashiki, Japan.
Hironobu OhumiDepartment of Hepatology and Pancreatology, Kawasaki Medical School, Kurashiki, Japan.
Yasuyuki TomiyamaDepartment of Hepatology and Pancreatology, Kawasaki Medical School, Kurashiki, Japan.
Akihiko KankiDepartment of Radiology, Kawasaki Medical School, Kurashiki, Japan.
Hidemitsu SotozonoDepartment of Radiology, Kawasaki Medical School, Kurashiki, Japan.
Seiya HashimotoDepartment of Hematology, Kawasaki Medical School, Kurashiki, Japan.
Harunoshin YasuiDepartment of Hematology, Kawasaki Medical School, Kurashiki, Japan.
Risa ShimizuDepartment of Hematology, Kawasaki Medical School, Kurashiki, Japan.
Keisuke HinoDepartment of Hepatology and Pancreatology, Kawasaki Medical School, Kurashiki, Japan.
Eisei KondoDepartment of Hematology, Kawasaki Medical School, Kurashiki, Japan.
Hideho WadaDepartment of Hematology, Kawasaki Medical School, Kurashiki, Japan.
Kawasaki Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human immunodeficiency virus (HIV) infection is often complicated with hepatitis virus infection. Antiretroviral therapy (ART) should be initiated with caution for patients with severe virus- or drug-induced acute hepatitis while considering factors that might interfere with the initiation of therapy. Case report: Herein, we present a case of a 67-year-old woman who presented with symptoms of severe liver injury of unknown cause. Laboratory examinations revealed HIV infection. The HIV viral load was high, and treatment with ART was considered. However, a liver biopsy could not be performed because of hyperbilirubinemia and the risk of severe hepatic damage. After assessing the risk of further liver damage, ART was safely administered despite hyperbilirubinemia. Treatment with ART could successfully reduce the viral load and bilirubin levels. Conclusion: ART treatment could be safely used for patients with HIV to reduce the viral load and bilirubin levels while avoiding the risk of liver failure.

Indexed as

Antiretroviral therapyHIV-Associated cholangiopathy

Identifiers

PMID36411911
PMCPMC9674489
OpenAlexW4308979118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.