Evidence map›Paper›PMID 36411878›Full record

ArticleEpilepsy & behavior reports2022

Multimodal approach leads to seizure-freedom in a case of highly refractory drug-resistant focal epilepsy.

Kelsey M Smith, Eva C Alden, Hugh D Simpson, Benjamin H Brinkmann, Nicholas M Gregg, Kai J Miller, Brian N Lundstrom

Abstract readCase Reports
In one paragraph

Article in Epilepsy & behavior reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kelsey M SmithDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States.
Eva C AldenDepartment of Psychology and Psychiatry, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States.
Hugh D SimpsonDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States.
Benjamin H BrinkmannDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States.
Nicholas M GreggDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States.
Kai J MillerDepartment of Neurologic Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States.
Brian N LundstromDepartment of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States.

Funding

Localizing value and underlying mechanisms of low frequency EEG for focal epilepsyK23NS112339 · NINDS · MAYO CLINIC ROCHESTER · PI LUNDSTROM, BRIAN NILS · 2019 to 2023
$935k
NINDS NIH HHS K23 NS112339
6 · The paper itself

Abstract

Drug-resistant, nonlesional, extratemporal lobe focal epilepsy can be difficult to treat and may require a high degree of multidisciplinary teamwork to localize the seizure onset zone for resective surgery. Here, we describe a patient with longstanding drug-resistant, nonlesional, extratemporal focal epilepsy with a high seizure burden who became seizure-free after prolonged evaluation and eventual left frontal cortical resection. Prior evaluations included magnetoencephalography, invasive video-EEG monitoring, and implantation of a responsive neurostimulation (RNS) device for ongoing intracranial stimulation. Highly sophisticated techniques were utilized including stereotactic localization of prior evaluations to guide repeat stereo-EEG (SEEG), electrical stimulation mapping, SEEG-guided radiofrequency ablation, and awake resection with language and motor mapping using a cognitive testing platform . Incorporating a wide array of data from multiple centers and evaluation time periods was necessary to optimize seizure control and minimize the risk of neurological deficits from surgery.

Indexed as

ASMs, anti-seizure medicationsAwake cortical resectionElectrical stimulation mappingEMU, epilepsy monitoring unitEpilepsy surgeryESM, electrical stimulation mappingRNS, responsive neurostimulationSEEGSEEG-guided radiofrequency ablationSEEG, stereo-EEGSMA, supplementary motor areaSOZ, seizure onset zone

Identifiers

PMID36411878
PMCPMC9674497

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.