ReviewSubstance abuse and rehabilitation2022
An Umbrella Review of the Links Between Adverse Childhood Experiences and Substance Misuse: What, Why, and Where Do We Go from Here?
Review in Substance abuse and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits.Journal of adolescence · 2026Article
- Why Prevention Needs More Than Individual Empowerment: Reclaiming Environmental Prevention.Journal of prevention (2022) · 2026Article
- Individual Contributions of Adverse Childhood Experiences to Adolescent Substance Use.Substance use & misuse · 2026Article
- Adverse Effects of Non-Medical Use of Cannabis or Opioids Associated with Adverse Childhood Experiences.International journal of environmental research and public health · 2026Article
- Bullying as an Adverse Childhood Experience?-State of the Art.Children (Basel, Switzerland) · 2026Review
- Predicting Substance Use in Young Adults: The Role of Childhood Adversity.Medicina (Kaunas, Lithuania) · 2026Article
- Childhood maltreatment and early-onset substance use: sex differences in the impact of various types of maltreatment and psychiatric comorbidity.BMC psychiatry · 2026Article
- The Mediating Role of Alcohol Use Between Adverse Childhood Experiences and Delinquency Among Youth in the Legal System.International journal of environmental research and public health · 2026Article
- The relationship between 3,4-methylenedioxymethamphetamine (MDMA) use in young adulthood and anxiety or depressive disorders in the mid-30s: Findings from the Victorian Adolescent Health Cohort Study.Addiction (Abingdon, England) · 2025Article
- Prevalence of adverse childhood experiences among individuals in treatment for substance use disorder: are ACE associated differently across type of abuse and quantity of consumption?International journal of circumpolar health · 2025Article
- Multivariable machine learning prediction of risky alcohol use in contemporary youth.Addiction (Abingdon, England) · 2025Article
- Exploring Pathways from Childhood Adversity to Substance Use in Young Adults.International journal of environmental research and public health · 2025Article
- Exploring the Relationship Between Adverse Childhood Experiences and Internalized Substance Use Stigma: A Mediation Analysis Among Incarcerated Women.Stigma and health · 2025Article
- Exploring the impact of drug decriminalization and legalization policies on mental health outcomes: A scoping review.PLOS mental health · 2025Article
- Positive Childhood Experiences are Associated With Alcohol Use in Adolescent and Emerging Adult Females by Adverse Childhood Experiences Dimension.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2024Article
- Refining the Universal, School-Based OurFutures Mental Health Program to Be Trauma Informed, Gender and Sexuality Diversity Affirmative, and Adherent to Proportionate Universalism: Mixed Methods Participatory Design Process.JMIR pediatrics and parenting · 2024Article
- Art therapy's engagement of brain networks for enduring recovery from addiction.Frontiers in psychiatry · 2024Article
- Adverse Childhood Experiences and Mental Health among Students Seeking Psychological Counseling Services.International journal of environmental research and public health · 2023Article
- Age, β-endorphin, and sex dependent effects of maternal separation on locomotor activity, anxiety-like behavior, and alcohol reward.Frontiers in behavioral neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: A wealth of research has identified adverse childhood experiences (ACEs; abuse, neglect, violence or disorder in the home) as a strong risk factor for substance misuse. Synthesis of the existing evidence is critical to shape policy and inform directions for future research. Existing reviews have focused on specific substances or substance use outcomes (eg, disorder), and do not include discussion of the mechanisms that operate between ACEs and substance misuse. The current umbrella review aims to synthesize reviews on the relationship between ACEs and substance misuse, review the evidence on the mechanisms linking these, identify existing gaps in our knowledge, and discuss critical directions for future research, practice, and public policy. Methods: Two electronic databases (PsycINFO and Medline) were searched for reviews published between 1998 and 2022 on the link between ACEs and substance misuse. Twenty articles met eligibility criteria and were qualitatively synthesized. Results: Results overwhelmingly demonstrated an elevated risk of substance misuse or disorder, among adolescents and adults exposed to ACEs. Research on the mechanisms that explain this link highlights a multitude of potential intervention targets, with childhood stress propelling a cascade of effects across neurobiological, endocrine, immune, metabolic, and nervous systems, impacting psychosocial and cognitive functioning. Nonetheless, the literature is subject to limitations surrounding potential unmeasured cofounders and causality, as well as decontextualizing childhood adversity from broader structural issues that influence the link between ACEs and substance misuse. Research, policy, and practice that seek to holistically understand and address the relationship between ACEs and substance misuse within the broader social determinants of health is crucial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.