Evidence map›Paper›PMID 36411766›Full record

ArticleInternational journal of nanomedicine2022

Photodynamic Therapy and Antibacterial Activities of a Novel Synthesized Quaternary Zn-Cu-In-S/ZnS QDs- mTHPP Porphyrin Conjugate.

Ncediwe Tsolekile, Sundararajan Parani, Erenilda Ferreira de Macedo, Thabang Calvin Lebepe, Rodney Maluleke, Vuyelwa Ncapayi, Mangaka Clara Matoetoe, Sandile Phinda Songca, Katia Conceição, Dayane Batista Tada and 1 more

Abstract read
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In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ncediwe TsolekileDepartment of Chemistry, Cape Peninsula University of Technology, Cape Town, 2000, South Africa.
Sundararajan ParaniDepartment of Chemical Sciences, University of Johannesburg, Johannesburg, 2028, South Africa.
Erenilda Ferreira de MacedoLaboratory of Nanomaterials and Nanotoxicology, Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-4274-8506
Thabang Calvin LebepeDepartment of Chemical Sciences, University of Johannesburg, Johannesburg, 2028, South Africa.
Rodney MalulekeDepartment of Chemical Sciences, University of Johannesburg, Johannesburg, 2028, South Africa.
Vuyelwa NcapayiDepartment of Chemical Sciences, University of Johannesburg, Johannesburg, 2028, South Africa.ORCID 0000-0002-0840-884X
Mangaka Clara MatoetoeDepartment of Chemistry, Cape Peninsula University of Technology, Cape Town, 2000, South Africa.
Sandile Phinda SongcaDepartment of Chemistry, University of KwaZulu-Natal, Durban, 4000, South Africa.ORCID 0000-0003-2522-5567
Katia ConceiçãoLaboratory of Peptide Biochemistry, Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil.
Dayane Batista TadaLaboratory of Nanomaterials and Nanotoxicology, Institute of Science and Technology, Federal University of São Paulo, São Paulo, Brazil.
Oluwatobi Samuel OluwafemiDepartment of Chemical Sciences, University of Johannesburg, Johannesburg, 2028, South Africa.ORCID 0000-0001-8964-5646

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Photodynamic therapy (PDT) is a non-invasive treatment modality that destroys abnormally growing cells or microorganisms. Porphyrins are used as photosensitizers in PDT; however, their clinical application has been limited by their poor water solubility, resulting in aggregation and low quantum yields of reactive oxygen species (ROS). Methods: To overcome these limitations and improve PDT efficacy, we herein report the conjugation of ZnCuInS/ZnS (ZCIS/ZnS) quantum dots (QDs) to 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (mTHPP). The optimal conditions for QDs porphyrin conjugation formation were systematically evaluated. Discussion: This study further assessed the PDT efficacy and antibacterial potency of the synthesized ZCIS/ZnS-mTHPP conjugates. The PDT efficacy of the QDs, mTHPP, and conjugate was evaluated against the murine metastatic melanoma (B16 F10 Nex2) cell line. This was performed with and without LED irradiation. Results: The conjugate exhibited the highest reduction in cell viability following LED irradiation (72%) compared to the bare QDs (19%) and mTHPP (1%). Antimicrobial studies conducted on Conclusion: The results suggest that conjugate is a promising class of materials for anti-cancer and antimicrobial PDT.

Indexed as

PhotochemotherapyPorphyrinsQuantum DotsAlloysAnimalsAnti-Bacterial AgentsEscherichia coliMiceSulfidesZincZinc CompoundsAlloysAnti-Bacterial AgentsPorphyrinsSulfidestetra(3-hydroxyphenyl)porphineZCISZincZinc Compoundszinc sulfide5,10,15,20-tetrakis(hydroxyphenyl)porphyrinantibacterial activitymTHPPmurine metastatic melanoma (B16F10-Nex2)photodynamic therapyZn-Cu-In-S/ZnS QDs

Identifiers

PMID36411766
PMCPMC9675416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.