Evidence map›Paper›PMID 36411704›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2022

Expression and function analysis of microRNA in collagen-induced arthritis rats.

Yuqi Wen, Cailin He, Yang Wang, Pin Chen, Xingui Xiong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuqi WenDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008. 208111147@csu.edu.cn.
Cailin HeDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008.
Yang WangDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008.
Pin ChenDepartment of Management Science and Engineering, Business School, Central South University, Changsha 410083, China.
Xingui XiongDepartment of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008. xiongxg07@csu.edu.cn.
Central South University · CN

Funding

the Key Program of Hunan Province Traditional Chinese Medicine Research C2022024the National Natural Science Foundation 81874407the Natural Science Foundation of Hunan Province 2019JJ40522
6 · The paper itself

Abstract

objectivesRheumatoid arthritis is a common autoimmune disease, and microRNAs (miRNAs) are involved in its pathogenesis. This study aims to examine the differentially expressed miRNAs in collagen-induced arthritis (CIA) rats, to analyze the biological functions and the related pathways of the miRNA target genes.

methodsThe total RNA in the synovium of experimental animals was extracted. The miRNA gene profile was obtained by miRNA microarray. Then the differentially expressed miRNAs were screened and the relevant target mRNAs were predicted. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed on the significantly differentially expressed miRNAs.

resultsThere were 69 differentially expressed miRNAs including rno-miR-6215 and rno-miR-709 in CIA rats, of which 22 (31.9%) were up-regulated and 47 (68.1%) were down-regulated. GO and KEGG enrichment analysis showed that the up-regulated miRNA target genes were mainly enriched in cellular metabolism, and they were involved in MAPK and Wnt signaling pathways. The down-regulated miRNA target genes were mainly enriched in nervous system development, and they were involved in axon guidance signaling pathway.

conclusionsThere are differentially expressed miRNAs in the CIA rat model, which may be involved in metabolism biological functions and signal pathways such as MAPK and Wnt.

Indexed as

Arthritis, ExperimentalMicroRNAsAnimalsRatsRNA, MessengerSynovial MembraneWnt Signaling PathwayMicroRNAsRNA, Messengercollagen-induced arthritis ratsmicroRNArheumatoid arthritis

Identifiers

PMID36411704
PMCPMC10930329
OpenAlexW4309658772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.