Evidence map›Paper›PMID 36411397›Full record

ReviewNature reviews. Microbiology2023

Molecular mechanisms of antibiotic resistance revisited.

Elizabeth M Darby, Eleftheria Trampari, Pauline Siasat, Maria Solsona Gaya, Ilyas Alav, Mark A Webber, Jessica M A Blair

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 575 papers.

0numbers the graph read from it
0cells of the map it votes in
575citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

575 citing papers in PubMed.

  1. Article
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  3. Drug-likeness prioritised selection identifies anti-Journal of enzyme inhibition and medicinal chemistry · 2026
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  5. Article
  6. Review
  7. Review
  8. Comparative efficacy of oral antibiotics against intracellular populations of uropathogenic Escherichia coli and bladder cell inflammatory response.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
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  15. Review
  16. Review
  17. Article
  18. Applicability of Nanopore-only whole-genome sequencing forJournal of clinical microbiology · 2026
    Article
  19. Article
  20. Article

515 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Elizabeth M DarbyCollege of Medical and Dental Sciences, Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6990-3537
Eleftheria TrampariQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0001-8886-8442
Pauline SiasatCollege of Medical and Dental Sciences, Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-4265-8604
Maria Solsona GayaQuadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0003-0654-2815
Ilyas AlavCollege of Medical and Dental Sciences, Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-7212-3371
Mark A WebberQuadram Institute Bioscience, Norwich Research Park, Norwich, UK. Mark.Webber@quadram.ac.uk.ORCID http://orcid.org/0000-0001-9169-7592
Jessica M A BlairCollege of Medical and Dental Sciences, Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK. J.M.A.Blair@bham.ac.uk.ORCID http://orcid.org/0000-0001-6904-4253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.

Indexed as

Anti-Bacterial AgentsBacteriaDrug Resistance, MicrobialGlobal HealthAnti-Bacterial Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.