ArticleNature chemistry2023
Adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) host for programmable surface functionalization.
Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Blood-Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control.Advanced healthcare materials · 2026Review
- Fibroblast-Mimetic Lignin Polymersomes for Logic-Gated Synthesis of Mechanically Reconfigurable Bioskins.Angewandte Chemie (International ed. in English) · 2026Article
- Architecture-Encoded Degradation Kinetics and Pathways through the Shape and Size of Polymeric Vesicles.Journal of the American Chemical Society · 2026Article
- Activating PEG host to enable spatially controlled surface functionalization of nanocarriers for biomedical applications.Science advances · 2025Article
- Dynamic pathways in energy landscapes guiding supramolecular Janus dendrimer self-assemblies between lamellar and cubic architectures.Nature communications · 2025Article
- Communicative Nanomotors Reprogram Cancer Cell Death via Pyroptosis.Angewandte Chemie (International ed. in English) · 2025Article
- Mechanophysical Synthesis of Core/Shell Hybrid Supraparticles.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- From "immune silence" to "immune dialogue": modification strategies for bone substitutes based on bone immunomodulatory characteristics.Frontiers in cell and developmental biology · 2025Review
- Kinetically controlled synthesis of rotaxane geometric isomers.Chemical science · 2024Article
- Review
- Unveiling the Antifouling Potential of Stabilized Poly(phosphorus ylides).ACS macro letters · 2023Article
- Porous Polymersomes as Carriers for Silver Nanoparticles and Nanoclusters: Advantages of Compartmentalization for Antimicrobial Usage.Biomacromolecules · 2023Article
- Tuning the Functionality of Self-Assembled 2D Platelets in the Third Dimension.Journal of the American Chemical Society · 2023Article
- Dynamic metastable polymersomes enable continuous flow manufacturing.Nature communications · 2023Article
- Post-transcriptional checkpoints in autoimmunity.Nature reviews. Rheumatology · 2023Review
- Complex Energy Landscapes of Self-Assembled Vesicles.Journal of the American Chemical Society · 2023Article
- Lipophilic Anchors that Embed Bioconjugates in Bilayer Membranes: A Review.Bioconjugate chemistry · 2023Review
- Molecular Engineering of pH-Responsive Anchoring Systems onto Poly(ethylene glycol) Corona.Journal of the American Chemical Society · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Covalent and non-covalent molecular binding are two strategies to tailor surface properties and functions. However, the lack of responsiveness and requirement for specific binding groups makes spatiotemporal control challenging. Here, we report the adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) (PEG) host as a non-covalent binding strategy for surface functionalization. By using polycyclic aromatic hydrocarbons as the hydrophobic anchor, hydrophilic charged and non-charged functional modules were spontaneously loaded onto PEG corona in 2 min without the assistance of any catalysts and binding groups. The thermodynamically favourable insertion of the hydrophobic anchor can be reversed by pulling the functional module, enabling programmable surface functionalization. We anticipate that the adaptive molecular recognition between the hydrophobic anchor and the PEG host will challenge the hydrophilic understanding of PEG and enhance the progress in nanomedicine, advanced materials and nanotechnology.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.