ArticleCommunications medicine2022
Dark-field chest X-ray imaging for the assessment of COVID-19-pneumonia.
Article in Communications medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Assessment of emphysema with simulated low-dose dark-field radiography.European radiology experimental · 2026Article
- Feasibility of longitudinal in vivo monitoring of pulmonary disease progression in mouse models using laboratory-based x-ray dark-field CT.European radiology experimental · 2026Article
- Beam-hardening correction in clinical x-ray dark-field chest radiography using deep-learning-based bone segmentation.Medical physics · 2026Article
- Look-up table correction for beam hardening-induced signal of clinical dark-field chest radiographs.Medical physics · 2026Article
- FaXToR: the hard X-ray micro-tomography beamline at the Spanish synchrotron ALBA.Journal of synchrotron radiation · 2026Article
- Deformable image registration of dark-field chest radiographs for functional lung assessment.Medical physics · 2025Article
- Multi-contrast machine learning improves schistosomiasis diagnostic performance.PLoS neglected tropical diseases · 2025Article
- Lung volume assessment for mean dark-field coefficient calculation using different determination methods.European radiology experimental · 2025Article
- Dark-field chest radiography signal characteristics in inspiration and expiration in healthy and emphysematous subjects.European radiology experimental · 2025Article
- A compact X-ray source via fast microparticle streams.Communications engineering · 2024Article
- Dark-field radiography for the detection of bone microstructure changes in osteoporotic human lumbar spine specimens.European radiology experimental · 2024Article
- Edge-illumination spectral phase-contrast tomography.Physics in medicine and biology · 2024Article
- Article
- Comparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia.Frontiers in radiology · 2024Article
- The choice of an autocorrelation length in dark-field lung imaging.Scientific reports · 2023Article
- Dark-field X-ray imaging for the assessment of osteoporosis in human lumbar spine specimens.Frontiers in physiology · 2023Article
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, alternative medical imaging methods for the assessment of pulmonary involvement in patients infected with COVID-19 are sought that combine a higher sensitivity than conventional (attenuation-based) chest radiography with a lower radiation dose than CT imaging.
methodsSixty patients with COVID-19-associated lung changes in a CT scan and 40 subjects without pathologic lung changes visible in the CT scan were included (in total, 100, 59 male, mean age 58 ± 14 years). All patients gave written informed consent. We employed a clinical setup for grating-based dark-field chest radiography, obtaining both a dark-field and a conventional attenuation image in one image acquisition. Attenuation images alone, dark-field images alone, and both displayed simultaneously were assessed for the presence of COVID-19-associated lung changes on a scale from 1 to 6 (1 = surely not, 6 = surely) by four blinded radiologists. Statistical analysis was performed by evaluation of the area under the receiver-operator-characteristics curves (AUC) using Obuchowski's method with a 0.05 level of significance.
resultsWe show that dark-field imaging has a higher sensitivity for COVID-19-pneumonia than attenuation-based imaging and that the combination of both is superior to one imaging modality alone. Furthermore, a quantitative image analysis shows a significant reduction of dark-field signals for COVID-19-patients.
conclusionsDark-field imaging complements and improves conventional radiography for the visualisation and detection of COVID-19-pneumonia.
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Registered trials
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