ArticleScientific reports2022
Triglyceride-glucose index is significantly associated with the risk of hyperuricemia in patients with diabetic kidney disease.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose-Response Meta-Analysis.Nutrients · 2025Pooled it
- The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Association of ABCG2 gene variants with urate levels in Mexican patients with type 2 diabetes and chronic kidney disease.Scientific reports · 2026Article
- Association between triglyceride-to-high-density lipoprotein cholesterol ratio and albuminuria in patients with type 2 diabetes: a cross-sectional study.Frontiers in nutrition · 2026Article
- Association Between Triglyceride-Glucose Index and Hyperuricemia in Hospitalized Patients with Depression: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2026Article
- Association of triglyceride-glucose index with diabetic kidney disease in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- Triglyceride-glucose index association with kidney function in adults; a population-based study.BMC endocrine disorders · 2025Article
- Association between triglyceride-glucose index and incidence risk of gout: a nationwide cohort study.Scientific reports · 2025Article
- Effect of Initial Glucose Tolerance Test Response on Pregnancy Outcomes in Type A1 Gestational Diabetes.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.Lipids in health and disease · 2025Article
- Association Between TyG-BMI Index and Hyperuricemia in Adult Women.Endocrinology, diabetes & metabolism · 2025Article
- Comparison of different insulin resistance surrogates in predicting hyperuricemia in non-diabetic Yi residents in Yunnan Province.Frontiers in endocrinology · 2025Article
- Lifestyle factors and hyperuricemia risk: a prospective cohort study of 14,635 participants examining the protective role of daily stair climbing.Frontiers in nutrition · 2025Article
- Association between the triglyceride-glucose index and hyperuricemia in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Host-derivedeLife · 2024Article
- The prognostic value of triglyceride-glucose index to adverse renal outcomes in patients with type 2 diabetes mellitus: results from the cohort study of ACCORD.Diabetology & metabolic syndrome · 2024Article
- Nonlinear association of triglyceride-glucose index with hyperuricemia in US adults: a cross-sectional study.Lipids in health and disease · 2024Article
- Associations of triglyceride-glucose index with hyperuricemia among Royal Thai Army personnel.BMC endocrine disorders · 2024Article
- Association between the triglyceride glucose index, triglyceride-glucose body mass index and diabetic kidney disease in adults with newly diagnosed type 2 diabetes.Frontiers in medicine · 2024Article
- Sex-Based Differences in the Associations Between Obesity- and Lipid-Related Indexes and Hyperuricemia Risk in Patients with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Triglyceride-glucose (TyG) index has been proposed to be a simple, economical, and reliable marker of insulin resistance. We aimed to investigate whether TyG is an independent predictor of hyperuricemia in diabetic kidney disease (DKD) populations by conducting a cross-sectional and longitudinal study. A total of 6,471 patients were enrolled in cross-sectional analysis, and 3,634 patients without hyperuricemia at the baseline were included in longitudinal analysis and were followed up for a median of 23.0 months. Hyperuricemia was categorized as a serum uric acid level ≥ 420 umol/L (7 mg/dL). In this study, 19.58% of participants had hyperuricemia. In the cross-sectional analysis, multivariate logistics regression analysis showed that the ORs (95% CI) for hyperuricemia in the second, third, and fourth TyG quartiles were 1.40 (95% CI 0.73-2.65), 1.69 (95% CI 0.90-3.18), and 4.53 (95% CI 2.39-8.57), respectively, compared with the first quartile. Longitudinally, the Kaplan-Meier survival analysis showed that higher TyG levels predicted higher incidence of hyperuricemia. Multivariate Cox regression model revealed that the hazard ratios for hyperuricemia in the upper quartiles of the TyG index were 1.69 (95% CI 0.97-2.93), 2.23 (95% CI 1.33-3.75), and 2.50 (95% CI 1.46-4.27), respectively, compared with the first quartile. Moreover, the subgroup analyses revealed that the relationship between TyG levels and hyperuricemia was robust in DKD patients. Our findings indicate a significant independent correlation between the TyG index and the risk of hyperuricemia in DKD patients.
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