Evidence map›Paper›PMID 36411085›Full record

ArticleACS chemical neuroscience2022

Hemispheric Utilization of Alpha Oscillatory Dynamics as a Unique Biomarker of Neural Compensation in Females with Fragile X Syndrome.

Jordan E Norris, Lisa A DeStefano, Lauren M Schmitt, Ernest V Pedapati, Craig A Erickson, John A Sweeney, Lauren E Ethridge

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
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  6. Alpha oscillations are dysrhythmic in Fragile X syndrome.bioRxiv : the preprint server for biology · 2026
    Article
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  12. Altered brain serotonin 5-HTNeuropharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jordan E NorrisDepartment of Psychology, University of Oklahoma, Norman, Oklahoma 73019, United States.ORCID 0000-0002-4438-3416
Lisa A DeStefanoDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, United States.
Lauren M SchmittDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, United States.
Ernest V PedapatiDivision of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, United States.
Craig A EricksonDivision of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, United States.
John A SweeneyDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio 45221, United States.
Lauren E EthridgeDepartment of Psychology, University of Oklahoma, Norman, Oklahoma 73019, United States.ORCID 0000-0003-0601-6911
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · USUniversity of Oklahoma · USUniversity of Oklahoma Health Sciences Center · US

Funding

Neurophysiological and acute pharmacological studies in FXS patientsU54HD082008 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI HUBER, KIMBERLY M. · 2014 to 2019
$9.8M
Translational medicine and mechanistic studies of brain neurophysiology in Fragile X SyndromeU54HD104461 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI HUBER, KIMBERLY M. · 2020 to 2024
$8.1M
Electrophysiological Biomarkers of Neurocognitive Deficits in Fragile X SyndromeK23HD101416 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI SCHMITT, LAUREN · 2020 to 2024
$617k
NICHD NIH HHS K23 HD101416NICHD NIH HHS U54 HD082008NICHD NIH HHS U54 HD104461
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a trinucleotide expansion on the FMR1 gene and characterized by intellectual disability, sensory hypersensitivity, executive function difficulties, and social anxiety. Recently, efforts to define neural biomarkers for FXS have highlighted disruptions to power in the alpha frequency band; however the dynamic mechanisms supporting these findings are poorly understood. The current study aimed to explore the temporal and hemispheric dynamics supporting alpha phenotypes in FXS and their relationship with neural phenotypes related to auditory processing using electroencephalography during an auditory evoked task. Adolescents and adults (

Indexed as

Alpha RhythmCerebrumFragile X SyndromeFemaleFragile X Messenger Ribonucleoprotein 1HumansMaleSex FactorsFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1Alpha powerasymmetryelectroencephalographylateralizationneurodevelopmental disordersex differences

Identifiers

PMID36411085
PMCPMC10199731
OpenAlexW4309521485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.