ArticleJournal of medical genetics2023
UK consensus recommendations for clinical management of cancer risk for women with germline pathogenic variants in cancer predisposition genes:
Open access · hybridAbstract readConsensus Statement
In one paragraph
Article in Journal of medical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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31citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 3% of its field
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
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- Economic evaluation of personalised versus conventional risk assessment for women who have undergone testing for hereditary breast and ovarian cancer genes: a modelling study.Journal of medical genetics · 2025Article
- Expanding the Genomic Landscape of HBOC and Cancer Risk Among Mutation Carriers.International journal of molecular sciences · 2025Article
- High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative breast cancer.Clinical epigenetics · 2025Article
- Role of solute carrier transporters in ovarian cancer (Review).International journal of molecular medicine · 2025Review
- Assessment of candidate high-grade serous ovarian carcinoma predisposition genes through integrated germline and tumour sequencing.NPJ genomic medicine · 2025Article
- Comprehensive Clinical Genetics, Molecular and Pathological Evaluation Efficiently Assist Diagnostics and Therapy Selection in Breast Cancer Patients with Hereditary Genetic Background.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
25 authors at 17 institutions in 1 country.
Helen HansonSouth West Thames Regional Genetic Services, St George's University Hospitals NHS Foundation Trust, London, UK helen.hanson@stgeorges.nhs.uk.ORCID 0000-0002-3303-8713
Anjana KulkarniDepartment of Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Lucy LoongDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK.
Grace KavanaughDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK.
Bethany TorrDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK.ORCID 0000-0003-3487-9749
Sophie AllenDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK.
Munaza AhmedNorth East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9223-3116
Ruth CleaverDepartment of Clinical Genetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
Tabib DabirNorthern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, UK.
D Gareth EvansManchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, UK.ORCID 0000-0002-8482-5784
Ellen GolightlyLothian Menopause Service, Chalmers Sexual Health Centre, Edinburgh, UK.
Rosalyn JewellDepartment of Clinical Genetics, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Kelly KohutSouth West Thames Regional Genetic Services, St George's University Hospitals NHS Foundation Trust, London, UK.
Ranjit ManchandaWolfson Institute of Population Health, Barts CRUK Cancer Centre, Queen Mary University of London, London, UK.ORCID 0000-0003-3381-5057
Alex MurrayAll Wales Medical Genomics Services, University Hospital of Wales, Cardiff, UK.
Jennie MurraySouth East Scotland Clinical Genetics Service, Western General Hospital, Edinburgh, UK.
Kai-Ren OngWest Midlands Regional Genetics Service, Birmingham Women's Hospital, Birmingham, UK.
Adam N RosenthalDepartment of Gynaecological Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
Emma Roisin WoodwardDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0002-6297-2855
Diana M EcclesCancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0002-9935-3169
Clare TurnbullDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK.ORCID 0000-0002-3797-7398
Marc TischkowitzDepartment of Medical Genetics, University of Cambridge, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK.
Consensus meeting attendees
Fiona LallooManchester Centre for Genomic Medicine, Central Manchester NHS Foundation Trust, Manchester, UK.
Institute of Cancer Research · GBManchester University NHS Foundation Trust · GBUniversity of Cambridge · GBUniversity of Manchester · GBBirmingham Women's Hospital · GBGreat Ormond Street Hospital · GBGuy's and St Thomas' NHS Foundation Trust · GBLeeds Teaching Hospitals NHS Trust · GBLothian Sexual Health · GBQueen Mary University of London · GBRoyal Devon & Exeter NHS Foundation Trust · GBSt George’s University Hospitals NHS Foundation Trust · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity Hospital of Wales · GBUniversity of Southampton · GBUniversity of Ulster · GBWestern General Hospital · GB
Funding
Cancer Research UK 27223Department of Health BRC-1215-20014
Abstract
Germline pathogenic variants (GPVs) in the cancer predisposition genes
Indexed as
Breast NeoplasmsDNA-Binding ProteinsFanconi Anemia Complementation Group N ProteinGenetic Predisposition to DiseaseOvarian NeoplasmsFanconi Anemia Complementation Group ProteinsFemaleGerm CellsGerm-Line MutationHumansMutS Homolog 2 ProteinRNA HelicasesUnited KingdomBRIP1 protein, humanDNA-Binding ProteinsFanconi Anemia Complementation Group N ProteinFanconi Anemia Complementation Group ProteinsMutS Homolog 2 ProteinPALB2 protein, humanRAD51C protein, humanRAD51D protein, humanRNA HelicasesClinical Decision-MakingDelivery of Health CareGenetic Carrier ScreeningGenetic Predisposition to DiseaseGynecology
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.