ArticleBMJ open2022
Comorbidity of mental ill-health in tuberculosis patients under treatment in a rural province of South Africa: a cross-sectional survey.
Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Prevalence of suicidal thoughts and behaviors among individuals with mental disorders in Africa: a systematic review and meta-analysis of the past 25 years.BMC psychiatry · 2026Pooled it
- Article
- Lived experiences of tuberculosis patients accessing treatment during COVID-19 in Zimbabwe.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
- Article
- Depression among people living with tuberculosis and tuberculosis/HIV coinfection in Ukraine: a cross-sectional study.Global health action · 2025Article
- Markers of pulmonary TB in care-seeking patients with respiratory symptoms.Public health action · 2025Article
- Current Landscape and Multidimensional Determinants of Spiritual Coping Mechanisms Among Tuberculosis Patients in Zhejiang, China: A Population-Based Cross-Sectional Investigation.Risk management and healthcare policy · 2025Article
- Mental Health Impacts of Multidrug-Resistant Tuberculosis in Patients and Household Contacts: A Mixed Methods Study.Cureus · 2024Article
- Possible depression in new tuberculosis patients in the Free State province, South Africa.Southern African journal of infectious diseases · 2024Article
- Piloting Siyakhana: A community health worker training to reduce substance use and depression stigma in South African HIV and TB care.PLOS global public health · 2024Article
- Psychiatric morbidity among patients on treatment for tuberculosis at a tertiary referral hospital in Western Kenya.PloS one · 2024Article
- The lived experiences of tuberculosis survivors during the COVID-19 pandemic and government lockdown in South Africa: a qualitative analysis.BMC public health · 2023Article
- Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China.Tropical medicine and infectious disease · 2023Article
- The lived experiences of Tuberculosis survivors during the COVID-19 pandemic and government lockdown in South Africa: a qualitative analysis.Research square · 2023Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTuberculosis (TB) remains prevalent despite the availability of effective anti-TB medications, and accumulating evidence suggests a high rate of mental disorders in people with TB. This is because TB and psychiatric disorders share several risk factors, such as poverty, homelessness and substance use disorder. Moreover, psychiatric comorbidities in patients with TB are associated with poor treatment outcomes. This study explored the psychiatric comorbidity and clinical correlates in individuals receiving TB treatment.
designA cross-sectional survey over 10 months.
settingTwo primary care clinics at King Sabata Dalindyebo district, Mthatha, Eastern Cape, South Africa. PARTICIPANT: Patients receiving TB treatment in the two clinics.
interventionThe Mini-International Neuropsychiatric Interview was used to screen for psychiatric disorders. PRIMARY AND SECONDARY OUTCOME MEASURES: Rates of mental disorders in patients with TB over a 10-month period. Variation in rates by sex, employment status and HIV comorbidity.
resultsIn a sample of 197 participants, most patients were men (62%) and screened positive for a mental disorder (82%) with anxiety (48%), depression (38%) and substance use disorders (43%) being the most common psychiatric conditions. On average, individuals had 4 (SD 2) mental disorders. Females had higher rates of depression (p=0.005) and non-adherence to TB treatment (p=0.003), and alcohol use disorder was more common in males (p<0.001) and in those non-adherent to TB treatment. Additionally, low education levels and unemployment were associated with depressive and anxiety disorders (p<0.05).
conclusionsMental disorders are common in patients with TB, and mental health services need to be integrated into the management of patients with TB. Factors linked to mental disorders in this cohort, such as low education, gender and unemployment, may be useful for compiling a risk profile to help identify those with TB who may require more intensive support for their mental health.
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