Evidence map›Paper›PMID 36410788›Full record

ArticleBMJ case reports2022

Response to sirolimus in a case of diffuse congenital hyperinsulinaemic hypoglycaemia due to homozygous

Chirantap Markand Oza, Vaman Khadilkar, Sandeep Kadam, Anuradha Khadilkar

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Protective Role of Octreotide in Acute and Chronic Lung Injuries.International journal of preventive medicine · 2026
    Article
  2. Octreotide and direct/indirect lung injury.Research in pharmaceutical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chirantap Markand OzaGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India.
Vaman KhadilkarGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India.
Sandeep KadamDepartment of pediatrics and neonatology, King Edward Memorial Hospital, Pune, Maharashtra, India.
Anuradha KhadilkarGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India anuradhavkhadilkar@gmail.com.ORCID http://orcid.org/0000-0001-9832-7033
Jehangir Hospital · INKing Edward Memorial Hospital Research Centre · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a male neonate with refractory and persistent neonatal hypoglycaemia not responding to octreotide. On evaluation for hypoglycaemia, his cortisol was within the reference range while the serum insulin concentrations were high. Gallium-68 dotatate scan (GA-68 DOTA) showed diffuse pancreatic involvement. Genetic diagnosis of congenital hyperinsulinaemic hypoglycaemia due to

Indexed as

Congenital HyperinsulinismSirolimusChildGallium RadioisotopesHumansInfant, NewbornMaleMutationPositron-Emission TomographyRadionuclide Imagingcopper dotatate CU-64Gallium-68Gallium RadioisotopesSirolimusDrugs: endocrine systemNeonatal intensive careUnwanted effects / adverse reactions

Identifiers

PMID36410788
PMCPMC9680149
OpenAlexW4309657656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.