Evidence map›Paper›PMID 36410718›Full record

ArticleNature2023

Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation.

Jonathan S Duke-Cohan, Aoi Akitsu, Robert J Mallis, Cameron M Messier, Patrick H Lizotte, Jon C Aster, Wonmuk Hwang, Matthew J Lang, Ellis L Reinherz

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Generation of effector CD4Stem cell reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Food for thought: Nutrient metabolism controlling early T cell development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. MHC class Ib-restricted CD8Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Harnessing αβ T cell receptor mechanobiology to achieve the promise of immuno-oncology.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jonathan S Duke-CohanLaboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA, USA. jonathan_duke-cohan@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-9478-9609
Aoi AkitsuLaboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA, USA.
Robert J MallisLaboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA, USA.
Cameron M MessierBelfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Patrick H LizotteBelfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9510-0036
Jon C AsterDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Wonmuk HwangDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0001-7514-3186
Matthew J LangDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-8198-144X
Ellis L ReinherzLaboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA, USA. ellis_reinherz@dfci.harvard.edu.ORCID http://orcid.org/0000-0003-1048-5526
Harvard University · USDana-Farber Cancer Institute · USBrigham and Women's Hospital · USTexas A&M University · USVanderbilt University · US

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6M
Protein Production CoreP01AI143565 · NIAID · DANA-FARBER CANCER INST · PI ELLIS L REINHERZ · 2020 to 2026
$19.9M
Understanding the structural basis of T cell receptor (TCR) and preTCR mechanosensing: single molecule, NMR and molecular dynamics studiesR01AI136301 · NIAID · VANDERBILT UNIVERSITY · PI LANG, MATTHEW J. · 2018 to 2022
$3.9M
NCI NIH HHS P30 CA006516NCI NIH HHS P30 CA006516-57NIAID NIH HHS P01 AI143565NIAID NIH HHS R01 AI136301
6 · The paper itself

Abstract

Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs in the thymus

Indexed as

Cell DedifferentiationHistocompatibility Antigens Class IReceptors, Antigen, T-CellThymocytesAnimalsMiceMice, KnockoutMolecular Docking SimulationPeptidesThymus GlandHistocompatibility Antigens Class IPeptidesReceptors, Antigen, T-Cell

Identifiers

PMID36410718
PMCPMC9851994
OpenAlexW4309668646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.