Evidence map›Paper›PMID 36410526›Full record

ReviewJournal of molecular and cellular cardiology2023

Mitochondrial permeability transition pore-dependent necrosis.

Dexter J Robichaux, Mikako Harata, Elizabeth Murphy, Jason Karch

Open access · greenAbstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  6. Review
  7. Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Dexter J RobichauxDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.
Mikako HarataCardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.
Elizabeth MurphyCardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.
Jason KarchDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA. Electronic address: karch@bcm.edu.
Baylor College of Medicine · USNational Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4M
Molecular Regulation of Mitochondrial Permeability Transition and its Role in Regulated NecrosisR01HL150031 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Jason Michael Karch · 2020 to 2026
$2.9M
NHLBI NIH HHS R01 HL150031
6 · The paper itself

Abstract

Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is triggered by increases in matrix levels of Ca

Indexed as

Mitochondrial Permeability Transition PoreMyocardial Reperfusion InjuryCell DeathHumansMitochondria, HeartMitochondrial Membrane Transport ProteinsNecrosisMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreANTATP synthaseBAKBAXCalciumCypDIschemia reperfusionMitochondriaMitochondrial dysfunctionMPTPNecrosisPermeability transitionROS

Identifiers

PMID36410526
PMCPMC9868081
OpenAlexW4309666802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.