Evidence map›Paper›PMID 36410384›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Potential Impact of Long-Acting Products on the Control of Tuberculosis: Preclinical Advancements and Translational Tools in Preventive Treatment.

Nicole C Ammerman, Eric L Nuermberger, Andrew Owen, Steve P Rannard, Caren Freel Meyers, Susan Swindells

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Preventing Multidrug-Resistant Tuberculosis: The Dawn of a New Era.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Nicole C AmmermanDepartment of Medical Microbiology and Infectious Diseases, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands.
Eric L NuermbergerCenter for Tuberculosis Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Andrew OwenCentre of Excellence for Long-acting Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Steve P RannardCentre of Excellence for Long-acting Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Caren Freel MeyersDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Susan SwindellsDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Johns Hopkins University · USUniversity of Liverpool · GBErasmus MC · NLUniversity of Nebraska Medical Center · US

Funding

Harnessing potent next-generation diarylquinolines for long-acting injectable formulations to prevent and treat tuberculosisR61AI161809 · NIAID · JOHNS HOPKINS UNIVERSITY · PI NUERMBERGER, ERIC L · 2021 to 2023
$1.7M
NIAID NIH HHS R61 AI161809
6 · The paper itself

Abstract

A key component of global tuberculosis (TB) control is the treatment of latent TB infection. The use of long-acting technologies to administer TB preventive treatment has the potential to significantly improve the delivery and impact of this important public health intervention. For example, an ideal long-acting treatment could consist of a single dose that could be administered in the clinic (ie, a "1-shot cure" for latent TB). Interest in long-acting formulations for TB preventive therapy has gained considerable traction in recent years. This article presents an overview of the specific considerations and current preclinical advancements relevant for the development of long-acting technologies of TB drugs for treatment of latent infection, including attributes of target product profiles, suitability of drugs for long-acting formulations, ongoing research efforts, and translation to clinical studies.

Indexed as

Latent TuberculosisTuberculosisAmbulatory Care FacilitiesAntibiotic ProphylaxisHumansPublic Healthlatent tuberculosis infectionlong-actingtuberculosistuberculosis preventive treatment

Identifiers

PMID36410384
PMCPMC10200320
OpenAlexW4309657290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.