ArticleThe American journal of tropical medicine and hygiene2023
What Historical Records Teach Us about the Discovery of Quinine.
Article in The American journal of tropical medicine and hygiene, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Malaria Prevention: Progress to Date.Drugs · 2026Review
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- Role of antimalarials in lupus nephritis: a narrative review.Clinical rheumatology · 2025Review
- Quinine and Quinidine Derivatives as Photosensitizers for Photodynamic Inactivation of Bacterial Pathogens.Journal of natural products · 2025Article
- Unveiling the anticancer potential of Pinostrobin: mechanisms of action, pharmacokinetic insights, and therapeutic prospects.Medical oncology (Northwood, London, England) · 2025Review
- Giovanni Battista Grassi (1854-1925): a forgotten Italian scholar and his fundamental studies on malaria.Journal of preventive medicine and hygiene · 2025Article
- Synergistic Antiviral Activity of European Black Elderberry Fruit Extract and Quinine Against SARS-CoV-2 and Influenza A Virusa.Nutrients · 2025Article
- Optimization of Two Methods for the Rapid and Effective Extraction of Quinine fromPlants (Basel, Switzerland) · 2025Article
- Ellagic Acid fromMolecules (Basel, Switzerland) · 2025Article
- The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria.Infectious disease reports · 2024Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The origin of quinine from Peru remains a mystery because of the lack of primary data-in particular, those produced by the Jesuits working in Peru. The discovery of cinchona bark and its use in malaria treatment must have come from the Jesuits, who worked with the native Andeans, the Quichuan people, and learned how the bark of the cinchona tree could be used for chills. Unknown is whether the Andean people used it for fever that may have been the result of malaria. We explored the literature of the 1600s, 1700s, and later to trace the history of quinine that is available. All these secondary sources lack the primary data of the Jesuits in their work with native Andeans, nor is there information on how the discovery of its use for malaria-like fevers came about. One clue comes from the Jesuits who talked with the Andean people and learned about quinine. But was it used for fever? Why did the Jesuits test it against (tertian or quartan) fevers that could have been the result of malaria? The gap in our knowledge can only be resolved with the discovery of written documents by the Jesuits about quinine for malaria.
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Registered trials
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