Evidence map›Paper›PMID 36410269›Full record

ArticleJournal of infection and public health2022

Rate of shed of SARS COV-2 viral RNA from COVID-19 cadavers.

Meenakshi Sharma, Megha Brijwal, Nabarun Chakraborty, Aashish Choudhary, Arbind Kumar, Sharad Srivastav, Parin Lalwani, Richa Agrawal, Kapil Dev Soni, Nirupam Madaan and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of infection and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. RT-PCR Result of SARS-CoV-2 Viral RNA in Cadavers and Viral Transmission Risk to Handlers.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Meenakshi SharmaDivision of Forensic Pathology and Molecular DNA, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: specialmeenakshi@gmail.com.
Megha BrijwalDepartment of Microbiology, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: megha.brijwal@yahoo.com.
Nabarun ChakrabortyDivision of Forensic Pathology and Molecular DNA, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: nabarun9816@gmail.com.
Aashish ChoudharyDepartment of Microbiology, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: aashishpath@yahoo.co.in.
Arbind KumarDepartment of Microbiology, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: arbind702@gmail.com.
Sharad SrivastavDepartment of Microbiology (Laboratory Medicine), Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: shrd2855@gmail.com.
Parin LalwaniDepartment of Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: drparinlalwani@gmail.com.
Richa AgrawalDepartment of Anaesthesia and Critical Care, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: pathakricha@yahoo.co.in.
Kapil Dev SoniDepartment of Anaesthesia and Critical Care, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: kdsoni111@gmail.com.
Nirupam MadaanDepartment of Hospital Administration, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: office.nirupam@gmail.com.
Rajesh MalhotraJai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: rmalhotra62@gmail.com.
Purva MathurDepartment of Microbiology (Laboratory Medicine), Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Room No. 325, Raj Nagar, New Delhi 110029, India. Electronic address: purvamathur@yahoo.co.in.
Sanjeev LalwaniDivision of Forensic Pathology and Molecular DNA, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, Raj Nagar, Room No. 116, New Delhi 110029, India. Electronic address: drsanjeevlalwani@gmail.com.
Lalit DarDepartment of Microbiology, All India Institute of Medical Sciences, Raj Nagar, New Delhi 110029, India. Electronic address: lalitdaraiims@gmail.com.
Anjan TrikhaDepartment of Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: anjantrikha@gmail.com.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAt what rate does the RNA of SARS CoV-2 shed from cadavers? Although, there have been numerous studies which have demonstrated the persistence of the virus on dead bodies, there is a lack of conclusive evidence regarding the variation of viral RNA content in cadavers. This has led to a knowledge gap regarding the safe handling/management of COVID-19 decedents, posing a barrier in forensic investigations.

methodsIn this study, we report the presence of RNA of SARS CoV-2 by real time RT-PCR, in nasopharyngeal swabs collected after death from two groups of bodies - one who died due to COVID-19 and the other who died due to other diagnoses. A prospective study on 199 corpses, who had tested positive for COVID-19 ante-mortem, was conducted at a tertiary care center. RNA testing was conducted at different time intervals (T1-T5).

results112(56.3%) died primarily due to COVID-19 and 87(43.7%) died due to other diagnoses. 144(72.4%) were male and 55(27.6%) were female. A total of 115 (57.8%) tested positive for COVID-19 after death at different time points. The mean age was 50.7 ± 18.9 years and the length of hospitalization ranged from 1 to 50 days with a mean of 9.2 ± 7.6 days. Realtime RT-PCR positivity of SARS CoV-2 RNA decreases with time.

conclusionWe observed that real time RT-PCR positivity, indicating viral RNA detection, decreases with time. Therefore, it is advisable to follow appropriate COVID-19 precautions to carry out scientific studies, medico-legal investigations and mortuary services on suspected/confirmed COVID-19 corpses.

Indexed as

COVID-19CadaverFemaleHumansInfantMaleProspective StudiesRNA, ViralSARS-CoV-2RNA, ViralAutopsyCOVID-19Public healthSARS-CoV-2Viral persistence

Identifiers

PMID36410269
PMCPMC9633634
OpenAlexW4308346876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.