ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023
Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis.
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Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Breaking the metabolo-immune cycle in primary biliary cholangitis for therapeutic benefit.Frontiers in immunology · 2026Review
- Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease.Hepatology (Baltimore, Md.) · 2025Review
- Portal Fibrosis and the Ductular Reaction: Pathophysiological Role in the Progression of Liver Disease and Translational Opportunities.Gastroenterology · 2025Review
- BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Unraveling the complexities of fibrosis and ductular reaction in liver disease: pathogenesis, mechanisms, and therapeutic insights.American journal of physiology. Cell physiology · 2024Review
- Review
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Authors and funding
20 authors at 4 institutions in 2 countries.
Vik MeadowsDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0002-8983-4305
Corinn MarakovitsDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Burcin EkserDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0003-0741-8007
Debjyoti KunduDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Tianhao ZhouDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Konstantina KyritsiDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Linh PhamDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Lixian ChenDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Lindsey KennedyDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0001-9224-8940
Ludovica CeciDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Nan WuDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Guido CarpinoDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico," Rome, Italy.
Wenjun ZhangDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0001-9801-0634
Abdulkadir IsidanDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Alison MeyerDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Travis OwenDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Eugenio GaudioDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Paolo OnoriDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Gianfranco AlpiniDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Heather FrancisDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0002-3466-3545
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USSapienza University of Rome · ITForo Italico University of Rome · IT
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MAlcohol-induced hepatotoxicity - implications of secretin/secretin receptor axisR01AA028711 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2020 to 2023
$2.2MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MMechanisms of mast cell/cholangiocyte regulation of non-alcoholic fatty liver disease progressionR01DK119421 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FRANCIS, HEATHER L · 2019 to 2022
$1.4MNeuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MRegulation of biliary growth and fibrosis by melatoninR01DK115184 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MRole of Sensory Innervation in High Fat Diet-Induced HepatotoxicityR01DK132891 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ALPINI, GIANFRANCO D, FRANCIS, HEATHER L · 2022 to 2023
$1.1MMast Cell Regulation of Alcohol-Induced Liver DamageR21AA030107 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI FRANCIS, HEATHER L · 2022 to 2023
$416kBLR&D Research Career Scientist AwardIK6BX005226 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2020 to 2024
–BLRD VA I01 BX000574BLRD VA I01 BX003031BLRD VA IK2 BX005306BLRD VA IK6 BX004601BLRD VA IK6 BX005226NIAAA NIH HHS R01 AA028711NIAAA NIH HHS R21 AA030107NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK110035NIDDK NIH HHS R01 DK115184NIDDK NIH HHS R01 DK119421NIDDK NIH HHS R01 DK132891
Abstract
Primary sclerosing cholangitis (PSC) is characterized by increased ductular reaction (DR), liver fibrosis, hepatic total bile acid (TBA) levels, and mast cell (MC) infiltration. Apical sodium BA transporter (ASBT) expression increases in cholestasis, and ileal inhibition reduces PSC phenotypes. FVB/NJ and multidrug-resistant 2 knockout (
Indexed as
Cholangitis, SclerosingCholestasisInflammatory Bowel DiseasesAnimalsBile Acids and SaltsCarrier ProteinsHistamineHumansInflammationLiverLiver CirrhosisMembrane GlycoproteinsMembrane Transport ProteinsMiceMorpholinosbile acid binding proteinsBile Acids and SaltsCarrier ProteinsHistamineMembrane GlycoproteinsMembrane Transport ProteinsMorpholinosbile acidscholehepatic shuntgut-liver axisprimary sclerosing cholangitis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.