Evidence map›Paper›PMID 36410022›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

Activation of TREK-1 (

Tatiana Zyrianova, Benjamin Lopez, Kathlyn Zou, Charles Gu, Dayna Pham, Sriharsha Talapaneni, Christopher M Waters, Riccardo Olcese, Andreas Schwingshackl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. KPharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Mechanisms of impaired alveolar fluid clearance.Anatomical record (Hoboken, N.J. : 2007) · 2025
    Review
  9. Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tatiana ZyrianovaDepartment of Pediatrics, University of California, Los Angeles, California.
Benjamin LopezDepartment of Pediatrics, University of California, Los Angeles, California.
Kathlyn ZouDepartment of Pediatrics, University of California, Los Angeles, California.
Charles GuDepartment of Pediatrics, University of California, Los Angeles, California.
Dayna PhamDepartment of Pediatrics, University of California, Los Angeles, California.
Sriharsha TalapaneniDepartment of Pediatrics, University of California, Los Angeles, California.
Christopher M WatersDepartment of Physiology, University of Kentucky, Lexington, Kentucky.ORCID 0000-0002-6706-1284
Riccardo OlceseDepartment of Anesthesiology & Perioperative Medicine, University of California, Los Angeles, California.
Andreas SchwingshacklDepartment of Pediatrics, University of California, Los Angeles, California.ORCID 0000-0002-5608-0199
University of California, Los Angeles · USUniversity of Kentucky · US

Funding

Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung InjuryR01HL146821 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHWINGSHACKL, ANDREAS · 2020 to 2024
$2.8M
The Role of TREK-1 potassium channels in ARDSR01HL175464 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Andreas Schwingshackl · 2024 to 2026
$2.3M
The Late L-type Ca Current as the Target for a New Class of AntiarrhythmicsR01HL134346 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2017 to 2020
$2.3M
Biophysical Mechanisms of Hyperoxia-Induced Lung InjuryR01HL151419 · NHLBI · UNIVERSITY OF KENTUCKY · PI WATERS, CHRISTOPHER M · 2020 to 2023
$2.1M
ASK1 and Ventilator-Induced Lung InjuryR01HL131526 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WATERS, CHRISTOPHER M · 2017 to 2020
$1.7M
The Role of 2-Pore Domain Potassium Channels in Acute Lung Injury.K08HL118118 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SCHWINGSHACKL, ANDREAS · 2014 to 2018
$792k
NHLBI NIH HHS K08 HL118118NHLBI NIH HHS R01 HL131526NHLBI NIH HHS R01 HL134346NHLBI NIH HHS R01 HL146821NHLBI NIH HHS R01 HL151419NHLBI NIH HHS R01 HL175464
6 · The paper itself

Abstract

Influenza-A virus (IAV) infects yearly an estimated one billion people worldwide, resulting in 300,000-650,000 deaths. Preventive vaccination programs and antiviral medications represent the mainstay of therapy, but with unacceptably high morbidity and mortality rates, new targeted therapeutic approaches are urgently needed. Since inflammatory processes are commonly associated with measurable changes in the cell membrane potential (Em), we investigated whether Em hyperpolarization via TREK-1 (

Indexed as

Acute Lung InjuryInfluenza A virusInfluenza, HumanOrthomyxoviridae InfectionsPotassium Channels, Tandem Pore DomainAnimalsChemokine CXCL10HumansInterleukin-6LungMiceTetrahydronaphthalenesTetrazoles(5,6,7,8-tetrahydronaphthalen-1-yl)-(2-(1H-tetrazol-5-yl)phenyl)amineChemokine CXCL10Interleukin-6potassium channel protein TREK-1Potassium Channels, Tandem Pore DomainTetrahydronaphthalenesTetrazolesacute lung injurycytokinesinflammationinfluenza virusTREK-1 (KCNK2) ion channels

Identifiers

PMID36410022
PMCPMC9829483
OpenAlexW4309655846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.