Evidence map›Paper›PMID 36409970›Full record

ArticleJCO precision oncology2022

Gene-Level Associations in Patients With and Without Pathogenic Germline Variants in

Esteban Astiazaran-Symonds, Cole Graham, Jung Kim, Margaret A Tucker, Christian Ingvar, Hildur Helgadottir, Lorenza Pastorino, Remco van Doorn, Joshua N Sampson, Bin Zhu and 18 more

Open access · greenAbstract read
In one paragraph

Article in JCO precision oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 10 institutions in 5 countries.

Esteban Astiazaran-SymondsDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.ORCID 0000-0001-8526-2576
Cole GrahamDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.ORCID 0000-0003-3088-329X
Jung KimDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.ORCID 0000-0001-6274-2841
Margaret A TuckerDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.ORCID 0000-0003-0274-6773
Christian IngvarDepartment of Surgery, Lund University Hospital, Lund, Sweden.
Hildur HelgadottirDepartment of Oncology Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-0735-4771
Lorenza PastorinoGenetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0002-2575-8331
Remco van DoornDepartment of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-7019-6673
Joshua N SampsonDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
Bin ZhuDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
William BrunoGenetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Paola QueiroloMelanoma Sarcoma and Rare Tumors, IEO European Institute of Oncology, Milano, Italy.
Giuseppe FornariniMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0003-4754-6572
Stefania ScialleroMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Brian CarterAmerican Cancer Society, Atlanta, GA.ORCID 0000-0003-1166-6521
Belynda HicksDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.ORCID 0000-0001-8014-4888
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.ORCID 0000-0002-4962-2711
Kristine JonesDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
Douglas R StewartDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.ORCID 0000-0001-8193-1488
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
Veronica HöiomDepartment of Oncology Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Susana PuigMelanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona and CIBERER, Barcelona, Spain.ORCID 0000-0003-1337-9745
Nelleke GruisDepartment of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-5210-9150
Xiaohong R YangDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
Paola GhiorzoGenetics of Rare Cancers, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0002-3651-8173
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD.
Division of Cancer Epidemiology and GeneticsOspedale Policlinico San Martino · ITLeidos (United States) · USKarolinska University Hospital · SELeiden University Medical Center · NLAmerican Cancer Society · USCentro de Investigación Biomédica en Red · ESEuropean Institute of Oncology · ITLund University · SEUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePancreatic ductal adenocarcinoma (PDAC) is a component of familial melanoma due to germline pathogenic variants (GPVs) in MATERIALS AND

methodsWe analyzed 189 cancer predisposition genes using parametric rare-variant association (RVA) tests and nonparametric permutation tests to identify gene-level associations in PDAC for patients with (

resultsIn RVA tests,

conclusionThese results suggest that variants in other genes likely play a role in PDAC in all patients and that PDAC in

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor ProteinsGenetic Predisposition to DiseaseGerm CellsHumansCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor Proteins

Identifiers

PMID36409970
PMCPMC10166474
OpenAlexW4309662339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.